ID F2UQS2_SALR5 Unreviewed; 1355 AA.
AC F2UQS2;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:EGD79977.1};
GN ORFNames=PTSG_10258 {ECO:0000313|EMBL:EGD79977.1};
OS Salpingoeca rosetta (strain ATCC 50818 / BSB-021).
OC Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Salpingoeca.
OX NCBI_TaxID=946362 {ECO:0000313|Proteomes:UP000007799};
RN [1] {ECO:0000313|Proteomes:UP000007799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50818 {ECO:0000313|Proteomes:UP000007799};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "Annotation of Salpingoeca rosetta.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL832989; EGD79977.1; -; Genomic_DNA.
DR RefSeq; XP_004988598.1; XM_004988541.1.
DR STRING; 946362.F2UQS2; -.
DR EnsemblProtists; EGD79977; EGD79977; PTSG_10258.
DR GeneID; 16069133; -.
DR KEGG; sre:PTSG_10258; -.
DR eggNOG; KOG0192; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; F2UQS2; -.
DR OMA; ALPRHCN; -.
DR OrthoDB; 5397075at2759; -.
DR Proteomes; UP000007799; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EGD79977.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007799};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EGD79977.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1355
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003287831"
FT TRANSMEM 971..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1031..1355
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 32..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1355 AA; 148231 MW; 94783613592D38FA CRC64;
MMMPGGRGRG LRLLVLLLGV AAVCVHASAP APAPVPAPAP APAPAPASSK HNHEAGTLCT
DVGMTLRRLT TTLQAFGVPV TPSSEHRFRS RTQQSQHGNF TPAAASTART TRARAHVAID
LSSIQRMMSA FGCAPTNGPS EDKGWQQQHH HHNQQQPTPS AHNQEAFPQT PPAPAHKGID
GNSSGNNFHL SPSRHHQQQQ QQQQQQHTRV RRSDEPTVQA GQCTLASVID GSCPGADAGG
RLTITLAEGD AVDDSTDAST LHAISPPVHE LTVIGHVEEE PLQWLVNSNW TFCTVITVEG
VRFPTFRLSI LNPLMNIHTV TIQDSELLRA VDARSFQHTA ALVTFRVIHC SLTSVPDVSG
MATLRILNLQ GNRVRRVGKS DLQGTPQLQQ LALSENVISK VELGALDGLS QLQTLILAAN
NITSTAGLFR SLPRLGILQL AQNPITRLEA DVFHALTRLT SLSIEYTRLT SLPPTLLAKA
TRLVRLFLTH NFITSLPDTI FSSLSSLNEL HLFSNRLTSL PPRVFKDLTA MTRLDLLNND
ISALPVGILD TCTRLLFFQC NSNRLTALPP NLFANAPKLQ QISFANNAIR TVNNALGLAA
LTALRLINLD HNQLTDLHLG AMLPSAVLLS LDNNPMRAVP DLSMTPALET FRMRNHRITH
IDLAPLLALP RLGVLEIGAS LQAQAKAVLP ANSNIANVAP LSTLGLENVD ISAIVSSLGQ
LASLSLDALH AGWPGATSDT LPMSALCAVL ASNVRELRIA NTDLSTIDLC PDKAFDVLLL
TDNRHLESVT VHDPLRELNV SGCTRLTSID APPIDILDIS STNLPLTGAL CTRWGRRVLF
ARNLGGVVDI RDAILSMRNC LEHVDVLDFS GNAWVSDVDE MNRITERTIA LSTSEFATAD
FGEIANRPMP PILQLTDAPI ECALELSNQD LRPLRNPIVV SAELVFSFHC TCARGFRMTS
GGRCVFNEPN ISTIVAASVI SGLAFGLLMA WLSRRYRGLT KRIGLQEQLL VERDEEVMAL
KKAWEIEYDE LRLVERVAAG AFGVVFKAEW DTVTVAVKVL QQSVMMFDES TVQEFEKEVE
FLQRTRHPNV VRFFGAGTDP NGSPFLVLEF VAMGSLKDLL GKDMEEVLME VRSRKVEESS
NGSVRDDVNR VWELKLRLLR DVASGMAFIH SLDQMHRDLK SGNVLVSSSL RAKITDFGSI
RQCFTRGGRA HGSRYTRLSS SHDVDDPQYS QQAGLQTMTS MTLTAGVGTP LYMAPEALTG
DKYSFEADIF SFGVLMWEVA TQRVPDLLEQ EKGSDFRGPM LATLSNLLQD GKRLRFDDSE
QDAIPEWFQS LTYKCMAQNP RARPSFGELK DHHFA
//
