ID   F2WWL7_STREE            Unreviewed;       703 AA.
AC   F2WWL7;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   13-SEP-2023, entry version 37.
DE   SubName: Full=Pneumococcal surface protein C {ECO:0000313|EMBL:ADZ45243.1};
DE   Flags: Fragment;
GN   Name=pspC {ECO:0000313|EMBL:ADZ45243.1};
OS   Streptococcus pneumoniae.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313 {ECO:0000313|EMBL:ADZ45243.1};
RN   [1] {ECO:0000313|EMBL:ADZ45243.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BHN42 {ECO:0000313|EMBL:ADZ45243.1};
RX   PubMed=19494311; DOI=10.4049/jimmunol.0802376;
RA   Dieudonne-Vatran A., Krentz S., Blom A.M., Meri S., Henriques-Normark B.,
RA   Riesbeck K., Albiger B.;
RT   "Clinical isolates of Streptococcus pneumoniae bind the complement
RT   inhibitor C4b-binding protein in a PspC allele-dependent fashion.";
RL   J. Immunol. 182:7865-7877(2009).
RN   [2] {ECO:0000313|EMBL:ADZ45243.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BHN42 {ECO:0000313|EMBL:ADZ45243.1};
RA   Hermans P.W.M., Albiger B.;
RT   "Does binding to the complement inhibitor C4b-binding protein, facilitate
RT   establishment and spread of multidrug-resistant pneumococcal clones in the
RT   community?";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HQ264143; ADZ45243.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2WWL7; -.
DR   Gene3D; 1.20.81.20; -; 1.
DR   Gene3D; 2.10.270.10; Cholin Binding; 3.
DR   Gene3D; 1.20.58.440; choline binding protein A; 2.
DR   Gene3D; 2.20.120.10; Multimodular pneumococcal cell wall endolysin, domain 3; 2.
DR   InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR   InterPro; IPR007756; RICH.
DR   InterPro; IPR038183; RICH_sf.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; NF033838; PspC_subgroup_1; 1.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   Pfam; PF01473; Choline_bind_1; 2.
DR   Pfam; PF19127; Choline_bind_3; 3.
DR   Pfam; PF05062; RICH; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF69360; Cell wall binding repeat; 2.
DR   PROSITE; PS51170; CW; 10.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          7..32
FT                   /note="YSIRK Gram-positive signal peptide"
FT                   /evidence="ECO:0000259|Pfam:PF04650"
FT   DOMAIN          53..135
FT                   /note="RICH"
FT                   /evidence="ECO:0000259|Pfam:PF05062"
FT   REPEAT          465..484
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          485..504
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          505..524
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          525..544
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          545..564
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          565..584
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          585..604
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          605..624
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          625..644
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REPEAT          645..664
FT                   /note="Cell wall-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT   REGION          198..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..445
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         703
FT                   /evidence="ECO:0000313|EMBL:ADZ45243.1"
SQ   SEQUENCE   703 AA;  79502 MW;  4C137CCDB8B33366 CRC64;
     MFASKSERKV HYSIRKFSIG VASVVVASLF LGGVVHAEGV RSGNNSTVTS SGQDISKKYA
     DEVESHLQSI LKDVNKNLKK VQHTQNVDFN KKLSAIKTKY LYELSVLEEK SEAELTSKTK
     ETKEELDAAF EQFKKDTLST EPEKKVAEAQ KKVAEAKKKA EAQKEEDHRN YPTITYKTLE
     LEIAEFDVKV KEAELELVKK EADESRNEGT INQAKAKVES EKAEATRLKK IKTDREKAEE
     EAKRRADAKE QDESKRRKSR VKRGDLGEQA TPDKKENDAK SSDSSVGEET LPSPSLKPGK
     KVAEAEKKVE EAKKKAEDQK EEDRRNYPTN TYKTLELEIA ESDVEVKKAE LELVKEEAKE
     PRNEEKVKQA KAEVESKKAE ATRLEKIKTD RKKAEEAKRK AAEEDKVKEK PAPKPENPAE
     QPKAEKPADQ QAEEDYARRS EEEYNRLTQQ QPPKTEKPAQ PSTPKTGWKQ ENGMWYFYNT
     DGSMATGWLQ NNGSWYYLNS NGAMATGWLQ NNGSWYYLNA NGSMATGWLQ NNGSWYYLNA
     NGSMATGWLQ NNGSWYYLNA NGSMATGWLQ NNGSWYYLNA NGAMATGWLQ NNGSWYYLNA
     NGSMATGWLQ NNGSWYYLNA NGSMATGWLQ YNGSWYYLNA NGSMATDWVK DGDTWYYLEA
     SGAMKASQWF KVSDKWYYVN GSGALAVNTT VDSYRVNANG EWV
//