ID   F2Y0I4_ANOGA            Unreviewed;       700 AA.
AC   F2Y0I4;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=APL1C {ECO:0000313|EMBL:ADZ44797.1};
GN   Name=APL1C {ECO:0000313|EMBL:ADZ44797.1};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:ADZ44797.1};
RN   [1] {ECO:0000313|EMBL:ADZ44797.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TM78 {ECO:0000313|EMBL:ADZ44797.1};
RX   PubMed=21408087; DOI=10.1371/journal.pbio.1000600;
RA   Rottschaefer S.M., Riehle M.M., Coulibaly B., Sacko M., Niare O.,
RA   Morlais I., Traore S.F., Vernick K.D., Lazzaro B.P.;
RT   "Exceptional Diversity, Maintenance of Polymorphism, and Recent Directional
RT   Selection on the APL1 Malaria Resistance Genes of Anopheles gambiae.";
RL   PLoS Biol. 9:E1000600-E1000600(2011).
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DR   EMBL; HQ702846; ADZ44797.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2Y0I4; -.
DR   VEuPathDB; VectorBase:AGAP007033; -.
DR   HOGENOM; CLU_022836_0_0_1; -.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR048481; LRIM1_APL1C-like_dimer.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24373:SF387; FISH-LIPS, ISOFORM E; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF20733; LRIM1_dimer; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..700
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003292795"
FT   DOMAIN          506..689
FT                   /note="LRIM1/APL1C-like dimerization"
FT                   /evidence="ECO:0000259|Pfam:PF20733"
FT   REGION          632..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          559..593
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   700 AA;  80008 MW;  F21DF3F2353D34F1 CRC64;
     MCWLHAVSLI SVIFFTCGSV AAVGGNNYWY TEEQPVATTK PSFHVNGYNI YGSQPANGGP
     TYRSETNFGG LTANGGLPAN GGLPANRGQL PYGTPTHIGQ TIYRSQANYG GQQRYNVRPR
     QHEYKCIERN LQYDCVFYDV HIDMQSQDVY FGFEDITLNN QKNVTFKNST MRKLPAALLA
     SYRQVELLDL NDLQIEQIDT NAFAYAHTIQ KLYMGFNAIR YLPPYVFHNV PLLTVLVLER
     NDLTSLPRGI FHNTPKLSML SMSNNNLERI EDDTFQATTA LQNLQLSSNR LTHVDLSLIP
     SLFHVNVSYN LLSTLAIPIA VEELDASHNS INAVRGPVNV ELTILKLQHN NLTDTAWLLN
     YPGLVEVDLS YNELEKIMYH PFVKMQRLER LYVSNNRLVA LNLYGQPIPT LKVLDLSHNH
     LLHVERNQPQ FDRLENLYLD HNSIVTLKLS THHTLKNLTL SHNDWDCNSL RALFINVARP
     AVDDADQHCK IDYQLEHGLC CKESDKPYLD RLLQYIALTS VVEKLQRAQG RCSATDTINS
     VQSLSHYITQ QGDVPLQGNE QLEAEVNELR AEVQQLTNEQ IQQEQLLQGL HAEIDTNLRR
     YRLPKDGLAR SSDNLNKVFT HLKERHAFKL RETQARRTEA DAKQKETEDL EQENIALEKQ
     LDNKKAKQAE LRQETSQKRQ KVKQLEAKKN RNPDTRRVTK
//