ID   F2YBK0_ANOGA            Unreviewed;       554 AA.
AC   F2YBK0;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=APL1B {ECO:0000313|EMBL:AEA41788.1};
GN   Name=APL1B {ECO:0000313|EMBL:AEA41788.1};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:AEA41788.1};
RN   [1] {ECO:0000313|EMBL:AEA41788.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BC03dry-10 {ECO:0000313|EMBL:AEA41788.1};
RX   PubMed=21408087; DOI=10.1371/journal.pbio.1000600;
RA   Rottschaefer S.M., Riehle M.M., Coulibaly B., Sacko M., Niare O.,
RA   Morlais I., Traore S.F., Vernick K.D., Lazzaro B.P.;
RT   "Exceptional Diversity, Maintenance of Polymorphism, and Recent Directional
RT   Selection on the APL1 Malaria Resistance Genes of Anopheles gambiae.";
RL   PLoS Biol. 9:E1000600-E1000600(2011).
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DR   EMBL; HQ860203; AEA41788.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2YBK0; -.
DR   HOGENOM; CLU_022836_0_0_1; -.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR048481; LRIM1_APL1C-like_dimer.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24366:SF152; GH22922P-RELATED; 1.
DR   PANTHER; PTHR24366; IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS; 1.
DR   Pfam; PF20733; LRIM1_dimer; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..554
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003290315"
FT   DOMAIN          366..549
FT                   /note="LRIM1/APL1C-like dimerization"
FT                   /evidence="ECO:0000259|Pfam:PF20733"
FT   REGION          494..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          418..452
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        494..517
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  64158 MW;  6A79AD7BED310755 CRC64;
     MCWLRAVSLI SMIFSASTYR GQLSYKSMHL THFTLSALLA SFHKVELLNL NGLQIEEIDT
     NAFAYAHTIQ KLYMRFNVIR YLPPHVFHNV PLLTVLMLDR NDLSSLPRGI FHNTPKLTML
     SMSNNNLERI EDDTFQATTS LQNLQLSSNR LTHVDLSLIP SLFHVNVSYN LLSTLAIPIA
     VEELDASHNR INVVRGPVNV ELAILKLQHN NLTDTAWLVN YPRLIEVNLS NNELEIITIH
     HFVKMQRLER LYISNNRLVA LDLYGRPIPT LKVLDLSHNH LMWVEHNQAQ FDKLQYLYLD
     HNSIVTLKLS TSHTLKNLTL SHNDWECNSL RALFRNVARP VVDDADQYCK IDYHLEHGLC
     CKESEKPYLD RLLQYIAMTS VVEKQRKNEP CSATDASNSA QSLYHYITQQ AVVSLQGNEQ
     LEAEVNELRA AVQQLTNEQI QQEQLLQGLH AEIDTNLRRF RLSNDELARP SENLNKVFTH
     LKERHAFKLR ETQARRTEAD AKQKETEDLE QENNALERQL DNKNTMQILL RQLTLLKRQQ
     IKQLLAKLSK HRPN
//