ID F2YWT6_9INFA Unreviewed; 299 AA.
AC F2YWT6;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ADZ96176.1};
OS Influenza A virus (A/chicken/Shanghai/Q0801-2/2008(H9N2)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC Alphainfluenzavirus influenzae; Influenza A virus.
OX NCBI_TaxID=996580 {ECO:0000313|EMBL:ADZ96176.1};
RN [1] {ECO:0000313|EMBL:ADZ96176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/chicken/Shanghai/Q0801-2/2008 {ECO:0000313|EMBL:ADZ96176.1};
RA Ge F.-F., Liu P.-H., Zhou J.-P., Liu J., Ju H.-B., Zhang W.-Y.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADZ96176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/chicken/Shanghai/Q0801-2/2008 {ECO:0000313|EMBL:ADZ96176.1};
RX PubMed=22407404; DOI=10.1007/s00705-012-1266-2;
RA Zhou J.P., Ge F.F., Liu J., Ju H.B., Yang D.Q., Wang J., Zhang W.Y.,
RA Liu P.H.;
RT "Epidemiological survey and genetic evolution of H9 subtype influenza
RT viruses in Shanghai, China, from 2006 to 2010.";
RL Arch. Virol. 157:1193-1198(2012).
CC -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC replication and transcription of virus RNA segments. The transcription
CC of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC transcription of viral mRNAs. During virus replication, PB1 initiates
CC RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC serves as a template for the production of more vRNAs.
CC {ECO:0000256|ARBA:ARBA00002148}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JF519804; ADZ96176.1; -; Viral_cRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 4: Predicted;
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host transcription shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022731};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host RNA polymerase II by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022484};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT DOMAIN 225..299
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ96176.1"
FT NON_TER 299
FT /evidence="ECO:0000313|EMBL:ADZ96176.1"
SQ SEQUENCE 299 AA; 34217 MW; 2F1DB0C5E1507FCB CRC64;
KAPQLNPIDG PLPDNNEPSG YAQTDCVLEA MAFLEESHPG IFENSCLETI EVVQQTRVDK
LTQGRQTYDW TLNRNQPAAT ALANTIEVFR SNGLTTNESG RLIDFLKDVM DSMNKEEMEI
TTHFQRKRRV RDNMTKKMIT QRTIGKKKQR LNRRSYLIRA LTLNTMTKDA ERGKLKRRAI
ATPGMQIRGF VYFVETLARS IGEKLEQSGL PVGGNEKKAK LANVVRKMMT NSQDTELSFT
ITGDNTKWKE NQNPRVFLAM ITYITRNQPE WLRNVLSIAP IMFSNKMARL GKGYMFESK
//
