ID F2Z5B4_PIG Unreviewed; 355 AA.
AC F2Z5B4; A0A480W0D5;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
GN Name=HNRNPA3 {ECO:0000313|Ensembl:ENSSSCP00000016940.5};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016940.5, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016940.5, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016940.5,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016940.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F2Z5B4; -.
DR STRING; 9823.ENSSSCP00000016940; -.
DR PaxDb; 9823-ENSSSCP00000016940; -.
DR PeptideAtlas; F2Z5B4; -.
DR Ensembl; ENSSSCT00000017409.5; ENSSSCP00000016940.5; ENSSSCG00000015988.5.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000153147; -.
DR HOGENOM; CLU_012062_1_0_1; -.
DR InParanoid; F2Z5B4; -.
DR OrthoDB; 3127428at2759; -.
DR TreeFam; TF314808; -.
DR Reactome; R-SSC-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-SSC-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000015988; Expressed in hindlimb bud and 44 other cell types or tissues.
DR ExpressionAtlas; F2Z5B4; baseline and differential.
DR Genevisible; F2Z5B4; SS.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12578; RRM1_hnRNPA_like; 1.
DR CDD; cd12582; RRM2_hnRNPA3; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034516; hnRNPA1/3_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48026; HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN; 1.
DR PANTHER; PTHR48026:SF26; RRM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..118
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 126..205
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 39880 MW; B0B9619F63514374 CRC64;
MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT
LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG
AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV
DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGEFFLP VLKVVEGDLA TLWVVAETLE
VVEATLAVAE TLVEEEVMVV EVVAAGVVME EAMVDIMDLE VMVATMVVVL VIVVEEAMVV
VDQDMGTKVV DMVAVVEDMM VTMKEEILEV VTMVVVGTIM ILEIIVDNNN QIMDP
//
