ID F2Z9J5_BOMMO Unreviewed; 878 AA.
AC F2Z9J5;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Nervous wreck S {ECO:0000313|EMBL:BAK22650.1};
GN Name=Bmnwk S {ECO:0000313|EMBL:BAK22650.1};
GN Synonyms=100616528 {ECO:0000313|EnsemblMetazoa:NP_001233136.1};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EMBL:BAK22650.1};
RN [1] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [2] {ECO:0000313|EMBL:BAK22650.1}
RP NUCLEOTIDE SEQUENCE.
RA Kiya T., Iwami M.;
RT "Identification and expression analysis of nervous wreck, which is
RT preferentially expressed in the brain of the male silkworm moth, Bombyx
RT mori.";
RL Insect Mol. Biol. 20:667-674(2011).
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001233136.1}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:NP_001233136.1};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
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DR EMBL; AB600240; BAK22650.1; -; mRNA.
DR RefSeq; NP_001233136.1; NM_001246207.1.
DR AlphaFoldDB; F2Z9J5; -.
DR EnsemblMetazoa; NM_001246207.1; NP_001233136.1; GeneID_100616528.
DR GeneID; 100616528; -.
DR KEGG; bmor:100616528; -.
DR CTD; 39052; -.
DR OrthoDB; 3674259at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR CDD; cd11761; SH3_FCHSD_1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035460; FCHSD_SH3_1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF20; PROTEIN NERVOUS WRECK; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..314
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 563..624
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 696..759
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 168..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..817
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 97427 MW; E3837BD8BD81BFC7 CRC64;
MQPPPRKSNY TKFLKNLHTE QIAKLHAKNQ HECDLLEDLR CYIVKRSSIE RSYSEALLKI
SSAYLNRKIP NIPDIKVDGA EEKWNMWNVW RTVLEENEKL ARARLAAVEV FQQHITDEAK
LLRHQKLSSA RKFTEGLAQA HKELQMTVGE VDKTKKLYFD EEHTAHDVRD KAKDIEENKP
SSSRGSPKHQ PPERNELVVD KYWLKKKKGS FFQSITSLQK NSAKVSSRRD QLEEKSTGAR
NDYILSIAAA NAHQNRYFLV DLQTCMQNME SSVYEKVSEY LTLMGRTELL TCSATQHSFG
KIRDQAQQLT REYNLQCLYL YYPVLKQHIQ YEFEPCDNDP IDTITMEHES VAVTLAQEAR
RWATRVVREA SLVRDANRKI SSYQAMRESG HKVDPNEPNG PELEVKMDEL RATIRRSEIS
KAKYEARLEC LRVGGAPVDD WLKEIDLLAV QETLPRSSSL LSVRTDASGA ADQPSSDSFY
DSDNTEGEAA ASVAGTSGSG GHQRTTSGSQ HEDDHEDEVD AALEIERQRI EQLAGGWDDP
TQVNWGESDP EPSTSEPIEP PAPPLYKCTA LYSYTAQNPD ELSIIENEQL EVVGEGDGDG
WLKARNYRGE EGYVPHNYLD VDHDQASSAP GLVSQISFSS VDYTVEGEDA DVVQSPDQIS
VISAPVGKPD EPTKAAEAAQ GEAAAVAQGP PKVDLPTLGY CFALYDYEAE ARDELNLEEG
QIIRVVSRNA HDVDDGWWRG ETNGIVGNFP SLIVEECDEN GEPLSVVEED WTPSGCAPPV
FASPPTSPPG ASDEAAVNES SAAPPLEPPP PPPADLGDSM DSQPDFSFNL ELTRNQQEQY
GMQFSEPAGP PVPPPVTIVG RRRDAAADAG GKACAAAS
//
