ID   F3ADH7_9FIRM            Unreviewed;      1255 AA.
AC   F3ADH7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Phosphoribosylformylglycinamidine synthase {ECO:0000313|EMBL:EGG84620.1};
GN   ORFNames=HMPREF0992_01122 {ECO:0000313|EMBL:EGG84620.1};
OS   Lachnospiraceae bacterium 6_1_63FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658083 {ECO:0000313|EMBL:EGG84620.1, ECO:0000313|Proteomes:UP000004368};
RN   [1] {ECO:0000313|EMBL:EGG84620.1, ECO:0000313|Proteomes:UP000004368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6_1_63FAA {ECO:0000313|EMBL:EGG84620.1,
RC   ECO:0000313|Proteomes:UP000004368};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA   Yandava C., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 6_1_63FAA.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGG84620.1}.
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DR   EMBL; ACTV01000011; EGG84620.1; -; Genomic_DNA.
DR   AlphaFoldDB; F3ADH7; -.
DR   HOGENOM; CLU_003100_2_0_9; -.
DR   OrthoDB; 9804441at2; -.
DR   Proteomes; UP000004368; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02203; PurL_repeat1; 1.
DR   CDD; cd02204; PurL_repeat2; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR010141; FGAM_synthase.
DR   InterPro; IPR041609; PurL_linker.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   NCBIfam; TIGR01857; FGAM-synthase; 1.
DR   PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR   PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   Pfam; PF18072; FGAR-AT_linker; 1.
DR   Pfam; PF13507; GATase_5; 1.
DR   SMART; SM01211; GATase_5; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT   DOMAIN          180..229
FT                   /note="Phosphoribosylformylglycinamidine synthase linker"
FT                   /evidence="ECO:0000259|Pfam:PF18072"
FT   DOMAIN          443..593
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   1255 AA;  138958 MW;  1AB89B184FAEB429 CRC64;
     MSSVKRVYVE KKQDFAVQAK ELKSEIEGYL GIKDVTGVRV LIRYDVENIS DEVFEKACTC
     VFSEPPVDDL FRETFEMAEN AKAFSVEYLP GQFDQRADSA VQCVQFLKED ETPIIRSATT
     YVIEGNISDE ELEAIKNHCI NPVDSREAEA AKPETLVTKF EEPEDVKIFD GFMEMPEADL
     QELYNSLNLA MTFKDFLHIQ NYYKNEEKRN PSMTEIRVLD TYWSDHCRHT TFSTELKNVT
     FGEGDYKEPI EKTYEKYLED RQVLYKDRDD KFVCLMDLAL MAMKKLKSEG KLQDQEESDE
     INACSIVVPV DVDGKEEEWL INFKNETHNH PTEIEPFGGA ATCLGGAIRD PLSGRTYVYQ
     AMRVTGAADP TVSVKETMKG KLPQKKLVRG AAHGYSSYGN QIGLATGYVK EIYHPDYVAK
     RMEIGAVLGA APRRGVIREN SDPGDIIILL GGRTGRDGCG GATGSSKVHT EESIETCGAE
     VQKGNAPTER KIQRLFRREE VSKIIKKCND FGAGGVSVAI GELAAGLKID LDKVPKKYAG
     LDGTEIAISE SQERMAVVID PKDVEKFLGF AKEENLEAIP VATVTEEPRL VMNWRGKTIV
     DLSRAFLDTN GAHQETDVFV EIPGKEDNAL TKTKEVKDVK EAWLSTLADL NTCSQKGLVE
     MFDGSIGAGS VFMPYGGKYQ LTETQTMVAK VPVLNGKTET VTMMSYGFDP YVSSWSPYHG
     AVYAVTESVA RIVAAGGDYS KIRFTFQEYF RRMTEDPHRW SQPFAALLGA YAAQLGFGLP
     SIGGKDSMSG SFNEIDVPPT LVSFAVDVAK QKDVITPELK NAGNKLVWLR APKASYDLPD
     FEALKEQYDK LHEDIQAGRV VSAYALDRQG IAAAVSKMAF GNQMGVKLCD SVEEAAVFGA
     GFGDIICEVA HDKVNELKMD CVVIGEVTDK AAFEYKDMTI SMAEALETWK APLENVFKTR
     SGSETDDATK SMDRGLYDTK EVHICSHKIA QPTVFIPVFP GTNCEYDSTK AFERAGAKVI
     TKVFKNLDAA DIRDSVDAFE KAIDQSQMIM FPGGFSAGDE PDGSAKFFAT AFRNEKMKEA
     VMRLLNERDG LALGICNGFQ ALIKLGLVPY GEIVGQTENS PTLTFNTIGR HISKIVYTKV
     VTNKSPWLLK AELGKVYANP ASHGEGRFVA NDEWLQKLFA NGQVATQYCD INGNVTMDEE
     WNVNGSYCAI EGITSPDGRV LGKMAHSERR GDGVAMNIYG EQDIKIFESG VEYFK
//