ID   F3AJ16_9FIRM            Unreviewed;       455 AA.
AC   F3AJ16;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0000259|Pfam:PF00905};
GN   ORFNames=HMPREF0987_00469 {ECO:0000313|EMBL:EGG88244.1};
OS   Lachnospiraceae bacterium 9_1_43BFAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658088 {ECO:0000313|EMBL:EGG88244.1, ECO:0000313|Proteomes:UP000003620};
RN   [1] {ECO:0000313|EMBL:EGG88244.1, ECO:0000313|Proteomes:UP000003620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9_1_43BFAA {ECO:0000313|EMBL:EGG88244.1,
RC   ECO:0000313|Proteomes:UP000003620};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA   Yandava C., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 9_1_43BFAA.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGG88244.1}.
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DR   EMBL; ACTX01000002; EGG88244.1; -; Genomic_DNA.
DR   AlphaFoldDB; F3AJ16; -.
DR   eggNOG; COG0768; Bacteria.
DR   HOGENOM; CLU_009289_1_0_9; -.
DR   Proteomes; UP000003620; Unassembled WGS sequence.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003620}.
FT   DOMAIN          142..449
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   455 AA;  49936 MW;  71A62B0597E63AC5 CRC64;
     MFVTLFLVLM GYIVYFNVVK SEKIINSPYN TRQDTFSDRV VRGSILDRNG EVLAKTEVAE
     DGSEMRTYPY GEVFAHVVGY DVNGKSGLES AENFNLLTSN AFFVERIIKE FQAKKNTGDS
     VVTTLDAKLQ TTAYNALGDE KGAVVVMEAD TGKILAMVSK PSFDPNSVED NWEYLNADNE
     QSPLLNRAMQ GAYAPGSIFK IVTALEYIRE QPAYGAYTYD CYGEITYDGT TIPCFNHIAH
     GFQDLNTSFA NSCNSSFANI GLSLDRKSYA KTCKQLLFNS KLPSVLDYRK SDFSLEETST
     SAEVMMTAMG QGDTQVSPYH MALITSAVAN GGKLMKPYLV SEVTNYTGTP VKKNKPSVYK
     ELMTAEEASI LTQYMTSVVT QGTGMELSGE SYSVAGKTGT AEYGSDGQSH SWFVGFTNVE
     DPELVVSVIV EGNEMQTGGR AIPVAKAIMN AYYYE
//