ID F3AV73_9FIRM Unreviewed; 1507 AA.
AC F3AV73;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=FtsK domain-containing protein {ECO:0000259|PROSITE:PS50901};
GN ORFNames=HMPREF1025_01627 {ECO:0000313|EMBL:EGG85444.1};
OS Lachnospiraceae bacterium 3_1_46FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=665950 {ECO:0000313|EMBL:EGG85444.1, ECO:0000313|Proteomes:UP000005376};
RN [1] {ECO:0000313|EMBL:EGG85444.1, ECO:0000313|Proteomes:UP000005376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_46FAA {ECO:0000313|EMBL:EGG85444.1,
RC ECO:0000313|Proteomes:UP000005376};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3_1_46FAA.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG85444.1}.
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DR EMBL; ACWP01000033; EGG85444.1; -; Genomic_DNA.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_003134_2_1_9; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000005376; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR023839; Firmicutes_EssC_C.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR NCBIfam; TIGR03928; T7_EssCb_Firm; 1.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50901; FTSK; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 668..862
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT DOMAIN 1006..1189
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 688..695
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT BINDING 1022..1029
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1507 AA; 170429 MW; 89EBA399AE7875FB CRC64;
MENRYKIILS GNQIYKEAEL PADMERVTVG TGIDCTVRLR RDLFFESIQI EFVKESGGWR
ATCSDNIYFT EGDIRKYMTR KVIHGDTLEV RYQESEGLVF RIDFQIDFDS GSHRCERMIN
LDRYQTISIG NNSAYEIALS GVYAKREFVR LTRGQGGWTL EVMNSEYGVY HNGKKTEQKE
WIKDGDFFSV ADYYFFLKGN ALWAEIRSDL TVNGLGFGDY PERNGYPRFS RNTRLKTVIC
EDKIEILDPP SKPQKPKSNL FMKLFPSFGM LIAAGAMAFM GGTMIIFSLI SCTIAIITAV
VGVMEGKKEF REKTANRIEV YQKYITSKRQ EIEECRNREW TERNEIYIPA EQEIQQVETF
SPDLFDRTPQ DEDFLCVRLG SGPIESARQV NYKKQEKLEI EDDLSLLPEQ TASFYKELQN
APVICDLKNV NAVGITGEEA DRFELLKLIV TDVALRHFAA DVKLFFVAEK EHAGRMHLFR
FLPGAYCAQT DTRGIVTDDE SKTLIFEYLY KELTMRAQEK RLYPHLLVFF YDEYGYKKHP
ISQFTEKGKD LGVTFLFFGQ TRADIPVGCD YVVQLSGGHR GVLINASKRS KTVPFVSSQI
SDTLAVRIVR TLAPVCTDEV SLEGELTKNI SMFKMLNILS VEDLDLKARW SASKVTKSMA
APVGVSKTGI VMLDLHDKAH GPHGLVAGTT GSGKSEILQT YILSMATLYH PYEAAFVIID
FKGGGMVNQF AQLPHLLGAI TNIDGNAINR SLKSIKAELQ KRQKYFAQAD VNHIDKYIRK
YKAGEVSEPL PHLIIIVDEF AELKAEQPEF MKELISAARI GRSLGVHLIL ATQKPAGQVN
EQIWSNSRFK LCLKVQSKED SNEVLKSPLA AEIKEPGRAY LQVGNNEIFE LFQSAYSGAP
EREDEGTGKA FTIYEVPDGG KKVPVYVKKK NKGQEGMKNQ LEAIVSYVSE YFRSIQIPQL
PDICLPPLGE CIEFPPVSKE AVQEQKKEVG FYAWIGVYDD PDHQNQDQYA VNLSAGNMII
IGSAQTGKTT ILQNVIRSLS EQYTPDEVAI YIIDFASMVL KNFETLNHVG GVVSSSEDEK
LKNLFKMLWE EMETRKEKLL SVGVSSFVAY KEAGRTDMKQ IVLIIDNLTA LKELYFQDDD
ELLNLCREGI TVGISIVIAN AQTAGIGYKY LSSFSNRIAL FCNDGNEYSA IFEHCNRRLE
HLPGRCFAEV DKQILECQAY LPFAGEKEFE RAEAIRGYIE KRNGECTEVA RKIPLIPPVL
SMNYMAQQFG NMMRGHFDLA AGLNYEDVMP YMLRMSSIGV LAVVGREGSG RHNWIKYVAD
MMELMYPGRS KVYISDGIGK KLASMKEKGN VVRYSMIAED IVSYLKEIEE ELQSRYELLA
KGIESDPAEA DYMLLIIDNP DAIEQISNSK EALASYKNII GRYRNMNVGV IISAIENAPI
PYSAPEVIKG IRDGRHLMYF GDISELKIYD MPLAVTRKFK KPIETGDGYY IKENECIKLK
TPFIAGE
//
