ID F3B639_9FIRM Unreviewed; 482 AA.
AC F3B639;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Biotin and thiamin synthesis-associated domain-containing protein {ECO:0000259|SMART:SM00876};
GN ORFNames=HMPREF0491_02503 {ECO:0000313|EMBL:EGG90981.1};
OS Lachnospiraceae oral taxon 107 str. F0167.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=575593 {ECO:0000313|EMBL:EGG90981.1, ECO:0000313|Proteomes:UP000003263};
RN [1] {ECO:0000313|EMBL:EGG90981.1, ECO:0000313|Proteomes:UP000003263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0167 {ECO:0000313|EMBL:EGG90981.1,
RC ECO:0000313|Proteomes:UP000003263};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium oral taxon 107 strain
RT F0167.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG90981.1}.
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DR EMBL; ADDS01000044; EGG90981.1; -; Genomic_DNA.
DR AlphaFoldDB; F3B639; -.
DR STRING; 575593.HMPREF0491_02503; -.
DR eggNOG; COG0502; Bacteria.
DR HOGENOM; CLU_046249_0_0_9; -.
DR OrthoDB; 9801120at2; -.
DR BioCyc; LORA575593-HMP:GMJL-2539-MONOMER; -.
DR Proteomes; UP000003263; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR GO; GO:0042364; P:water-soluble vitamin biosynthetic process; IEA:UniProt.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR024007; FeFe-hyd_mat_HydG.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR03955; rSAM_HydG; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF2; BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00319; Fe_hydrogenase_maturase_(HydG; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000003263};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 285..392
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 482 AA; 54789 MW; 25B7FAAF97BCBF53 CRC64;
MFKYDVNSKN AQEFINHEEI LATLKFADEN KNNIPLIEEY LEKARPKKTD KGIFAEGLNH
REAAVLLACE DKEVIKKIYD LAAEIKQTFY GNRIVMFAPL YLSNYCVNGC VYCPYHAKNK
RIARKKLTQE EIKNEVIALQ DMGHKRLAIE SGEDPINSPI EYILESLKTI YSIKHKNGAI
RRANVNIAAT TVENYKKLHD AGIGTYILFQ ETYNKESYES LHPTGPKHNY IYHTEAMDRA
MEGGIDDVGL GVLFGLESYR YEFAGLLMHA EHLESAFGVG PHTISVPRIK KADDIDPDAF
DNGLDDDTFE KIIACIRISV PYTGMIISTR ESQEVRERAL KVGISQISGA SRTSVGGYTE
EIRPTDSEQF DVSDQRSLDE VVDWLMHMGH IPSFCTACYR EGRTGDRFMS LCKSGQIINC
CHPNALMTLS EYMTDYASEQ TKSDGMEMIK HELEKISNPK VKERATDYIN QIETTNARDF
RF
//
