ID   F3M637_9BACL            Unreviewed;       768 AA.
AC   F3M637;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Putative penicillin-binding protein 2B {ECO:0000313|EMBL:EGG37161.1};
GN   ORFNames=HMPREF9412_1960 {ECO:0000313|EMBL:EGG37161.1};
OS   Paenibacillus sp. HGF5.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=908341 {ECO:0000313|EMBL:EGG37161.1, ECO:0000313|Proteomes:UP000004272};
RN   [1] {ECO:0000313|EMBL:EGG37161.1, ECO:0000313|Proteomes:UP000004272}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGF5 {ECO:0000313|EMBL:EGG37161.1,
RC   ECO:0000313|Proteomes:UP000004272};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Nelson K.E.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGG37161.1}.
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DR   EMBL; AEXS01000044; EGG37161.1; -; Genomic_DNA.
DR   RefSeq; WP_009590833.1; NZ_AEXS01000044.1.
DR   AlphaFoldDB; F3M637; -.
DR   OrthoDB; 9804124at2; -.
DR   Proteomes; UP000004272; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005543; PASTA_dom.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03793; PASTA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SMART; SM00740; PASTA; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR   PROSITE; PS51178; PASTA; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          597..659
FT                   /note="PASTA"
FT                   /evidence="ECO:0000259|PROSITE:PS51178"
FT   REGION          584..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..740
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   768 AA;  84076 MW;  BD3FBD08302A9A37 CRC64;
     MIKKIKLRTV LIGGCITLFF ALLIGRVFWL QVIDNDFWKE QALAKWSRTQ DLPASRGTIM
     DRDGDILAMD APAFTVIVNP AVIQANGLEN EVVKGLHETL GKDEDKLREM VQAKGKDGEY
     LKGVEVRNEG WKISQEKMEE VKEFSQSLND KLKAAGKVPD SGIGFQREQK RFYPKETLAA
     HMLGYTDRQG QGIGGIEQFY DEMLKGTDGF ASYKSDKKGV KLPSEDDLYQ PAINGKNLVL
     TTDDTIQYYI EEAMRDTYNQ YKPISMTVIA ADPNTMEILG MANMPTFDPN TYSKWNQKNF
     INHAVRSIYE PGSTFKIVTL ASAVQEKLFN PGDIYQSGSI RAGGRTHRDI NSVGWGPITY
     LEGVKKSSNV AFVKLGYEML GKERFTNYIR EFGFTEKTNI DLPGEILGTL NMTYDSDIST
     MTYGYAVSVT PIQQIAAISA VANGGKLMEP HMVKEIEDPN TGEVQKIEPK VVRQVISPEA
     ARETGTYLEQ VVADQVNGTG KLAYIDGYRV AGKTGTAIKS GGGYKDRSKQ VVSFIGYAPV
     ENPKIAVLVI IDEPNVEKGG GALAAPIFKE IVSKTLNYWG VPKTTETQDK EKSNPGTAPK
     DALKAPDFTG MKLSEVKAKL LKDGVAFETL GNGSTVKEQY PPANSIINVG QRIYLLTEDS
     PSMKIPNLEG ESLRDAMEVL TLMKVKVNVQ GEGFVASQLE AKENGQRIVQ LTLKSAQELI
     TGSSGSDETS SAGSANANGE ETGDKETEGT ADNEAEATDQ GQGDTEGE
//