ID F3URZ4_STRSA Unreviewed; 380 AA.
AC F3URZ4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Cysteine desulfurase {ECO:0000313|EMBL:EGJ38752.1};
DE EC=4.4.1.- {ECO:0000313|EMBL:EGJ38752.1};
GN Name=iscS {ECO:0000313|EMBL:EGJ38752.1};
GN ORFNames=HMPREF9389_1602 {ECO:0000313|EMBL:EGJ38752.1};
OS Streptococcus sanguinis SK355.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888816 {ECO:0000313|EMBL:EGJ38752.1, ECO:0000313|Proteomes:UP000005589};
RN [1] {ECO:0000313|EMBL:EGJ38752.1, ECO:0000313|Proteomes:UP000005589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK355 {ECO:0000313|EMBL:EGJ38752.1,
RC ECO:0000313|Proteomes:UP000005589};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU004504};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGJ38752.1}.
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DR EMBL; AFFN01000023; EGJ38752.1; -; Genomic_DNA.
DR RefSeq; WP_002930296.1; NZ_GL890993.1.
DR AlphaFoldDB; F3URZ4; -.
DR STRING; 888816.HMPREF9389_1602; -.
DR PATRIC; fig|888816.3.peg.1570; -.
DR eggNOG; COG1104; Bacteria.
DR HOGENOM; CLU_003433_0_0_9; -.
DR Proteomes; UP000005589; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.260.50; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR016454; Cysteine_dSase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601:SF50; CYSTEINE DESULFURASE ISCS 2-RELATED; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF005572; NifS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000313|EMBL:EGJ38752.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT DOMAIN 2..365
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
SQ SEQUENCE 380 AA; 41575 MW; 4F71360EDD78A849 CRC64;
MIYLDNSATT KPYPEALAAY TEVASKIWGN PSSLHSLGSQ ATRLLEASRR QIAELLGKSS
SEIFFTSGGT EGDNWVLKGV AFEKVPFGKH IIVSNIEHPA VKESALWLQS QGFEIDFAPV
DKSGIVEVDK LAELIRPDTT LISIMAVNNE IGSVQPIQKI SELLADKPTI SFHVDAVQAV
TKIPTAAYLT DRVDFATFSS HKFHGVRGVG FVYIKSGKKI SPLLTGGGQE SDKRSTTENL
AGIAATAKAL RLSMEKQEVF AQRTAQMKKI LLEELQKYPD VVIFSDLEDF APHILTFGIK
GVRGEVVVHA FENYEIYIST TSACSSKVGK PAGTLIAMGV EKSLAQTAVR ISLDADNDMS
QIEQFLTTFK IIYEKTRKVR
//
