ID F3UWV1_STRSA Unreviewed; 368 AA.
AC F3UWV1;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EGJ39791.1};
DE EC=1.3.1.13 {ECO:0000313|EMBL:EGJ39791.1};
GN Name=tyrA {ECO:0000313|EMBL:EGJ39791.1};
GN ORFNames=HMPREF9380_0989 {ECO:0000313|EMBL:EGJ39791.1};
OS Streptococcus sanguinis SK49.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888808 {ECO:0000313|EMBL:EGJ39791.1, ECO:0000313|Proteomes:UP000006459};
RN [1] {ECO:0000313|EMBL:EGJ39791.1, ECO:0000313|Proteomes:UP000006459}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK49 {ECO:0000313|EMBL:EGJ39791.1,
RC ECO:0000313|Proteomes:UP000006459};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGJ39791.1}.
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DR EMBL; AFFO01000008; EGJ39791.1; -; Genomic_DNA.
DR RefSeq; WP_002933218.1; NZ_GL890985.1.
DR AlphaFoldDB; F3UWV1; -.
DR PATRIC; fig|888808.3.peg.968; -.
DR eggNOG; COG0287; Bacteria.
DR HOGENOM; CLU_055968_2_1_9; -.
DR Proteomes; UP000006459; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EGJ39791.1}.
FT DOMAIN 4..294
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 368 AA; 41217 MW; 286F62170CDE4811 CRC64;
MERKTVYIVG LGLIGASLAL GIRRAHPEIE ILGYNRSEES RRVALERGMV DRVTDDFAAF
APLADVIILA VPIKQIIAFI KELAELDLKE NVIISDAGST KAEIVASAEK YLQNKPVRFV
GAHPMAGSHK TGAKAALVTL FENAYYIFTP SSLTKPGTLE EMKDLLSGLH ARFIQVDATE
HDRVTSQISH FPHILASSLM EQAAAYSQEH ELTQSFAAGG FRDMTRIAES EPGMWTSILL
TNPEAILERL EDFKDQLDKV AAAIEAKDER AIWEFFDRGR QSRKQMEIHK RAGVDSFYDL
FIEVPDEEDA ILGILELLRG ISVVNIRINE ENREDINGIL QITFKNHHDL EKSAKIVREN
TDYLVSED
//
