ID F4B432_ACIHW Unreviewed; 1136 AA.
AC F4B432;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Archaeal hydrophobe/amphiphile efflux-3 (HAE3) family protein {ECO:0000313|EMBL:AEE92996.1};
GN OrderedLocusNames=Ahos_0103 {ECO:0000313|EMBL:AEE92996.1};
OS Acidianus hospitalis (strain W1).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=933801 {ECO:0000313|EMBL:AEE92996.1, ECO:0000313|Proteomes:UP000008458};
RN [1] {ECO:0000313|EMBL:AEE92996.1, ECO:0000313|Proteomes:UP000008458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1 {ECO:0000313|EMBL:AEE92996.1,
RC ECO:0000313|Proteomes:UP000008458};
RX PubMed=21607549; DOI=10.1007/s00792-011-0379-y;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA She Q., Liu S.J., Garrett R.A.;
RT "Genomic analysis of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 15:487-497(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=W1;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA Liu S.J., Garrett R.A.;
RT "Genomic analyses of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002535; AEE92996.1; -; Genomic_DNA.
DR RefSeq; WP_013774913.1; NC_015518.1.
DR AlphaFoldDB; F4B432; -.
DR STRING; 933801.Ahos_0103; -.
DR GeneID; 10599543; -.
DR KEGG; aho:Ahos_0103; -.
DR eggNOG; arCOG02175; Archaea.
DR HOGENOM; CLU_276309_0_0_2; -.
DR OrthoDB; 42357at2157; -.
DR Proteomes; UP000008458; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 987..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1072..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 646..774
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 994..1123
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1136 AA; 128034 MW; 13218B5BBCE69CF4 CRC64;
MNSRFSEFIS KKWYVVLIIW IIVLAISAPF STLFFKSVSY QINISTPGST SAQAENIVSK
YFHLQGASGA NAILIIEGNV TPYSLFLANL TSYGNITVIS YYSLEKNLLN TTLSKLQNST
NSLYVKILEI KSGEIKAENN LSCKYIELNN TIVKLEELNY VTKKVEVAFI NVSNEINETT
IRLYQLHQGM LNNLSTFCKI KEGEMEINST AHNASLFLYG YTSLFLKNFL EIYNETHNFT
YSSEKAFEEV SKLINNVNES KFFYTFYKFW LESDCTNFVQ RAQISIENAS MLLPNNSFIL
YLENYINISN FEEGLPYYKF TVNYINETKH VPLELAEELY YNQPKDVLLN IYSEKTGLNE
TFLQEVLNQT NFKELAYDLI LSKANVTEKP FISAVYYNLN KSPYEFAVDY VSSQYNVSPT
LVNEISNFTE YSQYVNFVSL QASNESKLPQ WFFQQLLYYH NISNLTAYLI SPKLSKLQPI
LNASNITPKE FLIYLQTANN ESVYNLTAKL ISNYVNFTPI ICVNRSLLQE VLSRNESVSS
LVSELIRDNE FPVTPITNIT DALYYKNYYL IIMKGNFTIN EAKDFQNYVK SIIPLTSYLT
GPKPVDQQLR GLANSAFAIA IPVGIALAII ITGIYFRSFV AAFVPLGIYL SAFLVSSVLI
WLIVIKLLGI TVDFLTPSQV LLLALGLGTD YVVFISSRYI EERRNGLSKD EAVKEAVRWG
GRAVTLTALV VMLSFLFLYI YNVPLVSDTS ISEMLAVFVV WLSATTLFTS ILKAAGDKLF
FPAKFNRDNN TKSYSVSRPA TKVGIFITLV VIFSIIALSM PLSTNILGLM PPSQASEGVN
LLSQEFTTSN VFPIYVVVPI STFNQTTYNY AVHIYKELSS IPGVTAVESP VSPYGGLIPY
CKLSEYNYTE YISHGYMLFV VNQKYPPFST QAFGVVENIE SLHIGYVGGG PVDLYNILHF
IETDFLEIFL LITVTMYVLL VIMTRSFSVS GVVIFTIMSA VGITLGLERL IFVNILGYGI
FAVVPLFLVA IIIGIGMDYN IFLIARIHEE IEKEENMETA VGKSVKAIGK TIIFLGLIFA
GTMGSLMLVK AAILQEIGFA LSVAAILETS LLWYYLAPSL LVLLYRKFKI RPKMLI
//
