ID F4CDF7_SPHS2 Unreviewed; 1524 AA.
AC F4CDF7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family {ECO:0000313|EMBL:ADZ77692.1};
GN OrderedLocusNames=Sph21_1123 {ECO:0000313|EMBL:ADZ77692.1};
OS Sphingobacterium sp. (strain 21).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=743722 {ECO:0000313|EMBL:ADZ77692.1};
RN [1] {ECO:0000313|EMBL:ADZ77692.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=21 {ECO:0000313|EMBL:ADZ77692.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Siebers A.K.,
RA Allgaier M., Thelen M.P., Hugenholtz P., Woyke T.;
RT "Complete sequence of Sphingobacterium sp. 21.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane
CC {ECO:0000256|RuleBase:RU362097}; Lipid-anchor
CC {ECO:0000256|RuleBase:RU362097}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|RuleBase:RU362097}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP002584; ADZ77692.1; -; Genomic_DNA.
DR STRING; 743722.Sph21_1123; -.
DR KEGG; shg:Sph21_1123; -.
DR PATRIC; fig|743722.3.peg.1203; -.
DR eggNOG; COG0841; Bacteria.
DR eggNOG; COG1538; Bacteria.
DR HOGENOM; CLU_002755_1_1_10; -.
DR OrthoDB; 9758234at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR Gene3D; 2.20.200.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR010131; RND_efflux_OM_lipoprot_NodT.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR NCBIfam; TIGR01845; outer_NodT; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|RuleBase:RU362097};
KW Membrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|RuleBase:RU362097};
KW Transmembrane {ECO:0000256|RuleBase:RU362097, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|RuleBase:RU362097};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1524 AA; 167858 MW; 907581F80475BEF5 CRC64;
MFEIFIKRPV LSLVISLFIT LLGLLSLFTL PVTQFPDIVP PSVVVNANYT GANAEVSTNA
VAIPLEKAIN GVPGMTYMSS VSTNNGNTLI QVYFEVGTDP DIAAVNVQNR VTTVLDELPE
EVIKAGVTTE KEVNSMLMYL NIYSDDETAD ERFIYNFTDI NILKELKRIQ GVGRAEIMGF
KDYAMRVWLK PDRLTAYRVS SEDVIKAIRA QNVEAAPGQT GIGSDKSVNM QQYVLRYPGK
FDRPEQYENI PLRANPDGSI LRLRDVADVE FGSLEYEMAS KADGRPSASI MIKQLPGSNA
SEVIDAIKAK MEELKGTTFP PGMKYAMGYD VSRFLDASIN EVLHTLVEAF ILVFLVVFIF
LQDFRSTLVP ALAVPVCLIG ALFCMQMLGF SINLLTLFAL VLAIGIVVDN AIVVVEAVYV
KMEEEHMQPM EATLAAMREI SGAIIAITLV MSAVFVPVAF LSGPVGVFYR QFSLTLAGSI
LISGINALTL TPALCAIILR SPHDRPEPRG ALATFFRKFN SVYNSISGRY AGLISRIAGR
RVITLVILVV SFIATWGISS VLPSGFIPTE DQGMIYVNVT TPPGATVQRT EAVLDEVDAI
ARQMESVESV STLAGYSLVN EVTGASYGMG MINLKRWEER KESVSDMVEH MKKETAKITD
AEIEFFPPPT VPGFGNSSGF ELRVLDRSGS DDLGKLSDVL NTFMDNLKKA PEVGSAFTSF
DPNFPQYMIN VDYDVAAKKG ISVENAMSTL QTLMGSFYTS NFIKFGQMYK VMVQAGPGYR
EKPEDVLRLF LKNDAGEMVP FSSFIKMERI YGPEQLTRYN MFTSAMINGD AAPGYSSGDV
IAAVERVAAE SLPRGFEIEW SGMTREQILS GNQAIYVFAL CLLFVYLLLC AQYESFLLPL
PVILSLPAGV FGAFLFLKLL GLENNIYAQV ALIMLIGLLG KNAILIIEYA ILKHKQGASI
LNAAIEGSVA RLRPILMTSF AFVAGLIPLA MASGAGALGN RSIGTTAIGG MIIGTLAGVI
VIPGLYVLFA SMKKQKKAKK VSGIAVAVLG ILLLSSCGVQ KETELTHRKV PAHYLGKNQT
DTLANDSTSM ATISWRTFFQ DEYLLRLIDT ALANNPDMQQ ALYRVEMARA NMRLRKNALF
PSIDAVAEAG LRKYGFYTMD GIGNYDTNFS NNLKDDEQVP DPVPDYFLGL RASWEIDIWG
KLKNRKKAAF ARFLASYEGR KLVQTQLIAE IAAAYFELLA LDNELDILEK NIALQQESYE
LVQVQKEGGR ATELGVQQMR AILMNSKSRK ETVLQQINSK ENYLNFLCGR FSSPIERKQE
ELDAYPLASA VRVGLPAKML ALRPDIRAAE LNLLAAKGDV KAARAAFLPS LNFSPYFGFQ
AFDLSKLFVT SPSSIAYGLL GGLTAPIFNQ RMIRSNYEQE LANKGIEYQE YEKTVLKAWQ
EVETELNAQR HLIARRSFNQ HEVDALRLAV DASSELFKAG RANYLDVITS QRNVLDAEIT
LNSTYLEYLQ SIVNLYKALG GGWQ
//
