ID F4FZT7_METCR Unreviewed; 348 AA.
AC F4FZT7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=3-dehydroquinate synthase {ECO:0000313|EMBL:AEB94516.1};
GN OrderedLocusNames=Mcup_0408 {ECO:0000313|EMBL:AEB94516.1};
OS Metallosphaera cuprina (strain Ar-4).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=1006006 {ECO:0000313|EMBL:AEB94516.1, ECO:0000313|Proteomes:UP000007812};
RN [1] {ECO:0000313|EMBL:AEB94516.1, ECO:0000313|Proteomes:UP000007812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ar-4 {ECO:0000313|EMBL:AEB94516.1,
RC ECO:0000313|Proteomes:UP000007812};
RX PubMed=21551305; DOI=10.1128/JB.05038-11;
RA Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.;
RT "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-
RT oxidizing archaeon from a hot spring.";
RL J. Bacteriol. 193:3387-3388(2011).
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CP002656; AEB94516.1; -; Genomic_DNA.
DR RefSeq; WP_013737014.1; NC_015435.1.
DR AlphaFoldDB; F4FZT7; -.
DR STRING; 1006006.Mcup_0408; -.
DR GeneID; 10492602; -.
DR KEGG; mcn:Mcup_0408; -.
DR PATRIC; fig|1006006.8.peg.410; -.
DR eggNOG; arCOG00983; Archaea.
DR HOGENOM; CLU_001201_0_1_2; -.
DR OrthoDB; 21407at2157; -.
DR Proteomes; UP000007812; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR016037; DHQ_synth_AroB.
DR InterPro; IPR030963; DHQ_synth_fam.
DR InterPro; IPR030960; DHQS/DOIS.
DR NCBIfam; TIGR01357; aroB; 1.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF1; 3-DEHYDROQUINATE SYNTHASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR PIRSF; PIRSF001455; DHQ_synth; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 50..311
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 348 AA; 38665 MW; 8F3BD704769ADCB5 CRC64;
MIDFSEKICC SEVRVKIGRE VLGELDSLQG KKGIVHPRTL RTQLKADLDI EIEDGERGKD
ISVAMRIVDE LLSSGFTRGD YLIAMGGGTV LDVTGFSASI FMRGLNLINV PTTLLGMVDA
AIGGKNGVNY RLAKNMIGTF YQPFMIVEDL SFLDTLPVEE FRRGMAEVIK YALVLDKELY
DFLSLNHDSI MKRNQDVLEK VIYSSVKDKL FVVSEDERET KGVRIVLNFG HTIGHAIEAG
SDFKVPHGLA ISVGMVCEAK IAEEMGYAEE GVVEDVLWLL QLYGLPISMD QLNAKVEVER
ALKSMLMDKK RRGEETLMPF PTRIGNWRSV SVPNDTLVSF SKQCLGGN
//
