ID F4II93_ARATH Unreviewed; 613 AA.
AC F4II93;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Cyclic nucleotide-gated channel 12 {ECO:0000313|EMBL:AEC10698.1};
GN Name=CNGC12 {ECO:0000313|EMBL:AEC10698.1, ECO:0000313|TAIR:AT2G46450};
GN Synonyms=ATCNGC12 {ECO:0000313|EMBL:AEC10698.1};
GN OrderedLocusNames=At2g46450 {ECO:0000313|Araport:AT2G46450,
GN ECO:0000313|EMBL:AEC10698.1};
GN ORFNames=F11C10.14 {ECO:0000313|EMBL:AEC10698.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEC10698.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AEC10698.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S., Shea T.P., Benito M.I., Town C.D.,
RA Fujii C.Y., Mason T., Bowman C.L., Barnstead M., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBUNIT: Homotetramer or heterotetramer.
CC {ECO:0000256|ARBA:ARBA00011102}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000256|ARBA:ARBA00010486}.
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DR EMBL; CP002685; AEC10698.1; -; Genomic_DNA.
DR RefSeq; NP_001189758.1; NM_001202829.2.
DR AlphaFoldDB; F4II93; -.
DR ProteomicsDB; 219986; -.
DR EnsemblPlants; AT2G46450.3; AT2G46450.3; AT2G46450.
DR GeneID; 819253; -.
DR Gramene; AT2G46450.3; AT2G46450.3; AT2G46450.
DR Araport; AT2G46450; -.
DR TAIR; AT2G46450; CNGC12.
DR HOGENOM; CLU_013069_3_0_1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4II93; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45651:SF33; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 12-RELATED; 1.
DR PANTHER; PTHR45651; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW cGMP {ECO:0000256|ARBA:ARBA00022535};
KW cGMP-binding {ECO:0000256|ARBA:ARBA00022992};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022992};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F4II93,
KW ECO:0007829|ProteomicsDB:F4II93};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..472
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 582..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 70389 MW; D75401F95B8C9F19 CRC64;
MGVDGKLKSV RGRLKKVYGK MKTLENWRKT VLLACVVALA IDPLFLFIPL IDSQRFCFTF
DKTLVAVTIA PRSQASLRGE IVVHSKATLK TRLLFHFIVD IISVLPIPQV VVLTLIPLSA
SLVSERILKW IILSQYVPRI IRMYPLYKEV TRAFGTVAES KWAGAALNLF LYMLHSYVFG
AFWYLSSIER KSKCWRAACA RTSDCNLTVT DLLCKRAGSD NIRFLNTSCP LIDPAQITNS
TDFDFGMYID ALKSGVLEVK PKDFPRKFVY CFWWGLRNIS ALGQNLETSN SAGEIFFAII
ICVSGLLLFA VLIGNVQKYL QSSTTRVDEM EEKRRDTEKW MSYRVIPEYL KERIRRFEDY
KWRETKGTEE EALLRSLPKD LRLETKRYLY LDMLKRVPWL NIMDDGWLLE AVCDRVKSVF
YLANSFIVRE GHPVEEMLIV TRGKLKSTTG SHEMGVRNNC CDLQDGDICG ELLFNGSRLP
TSTRTVMTLT EVEGFILLPD DIKFIASHLN VFQRQKLQRT FRLYSQQWRS WAAFFIQAAW
RKHCKRKLSK TRDNENIPQG TQLNLASTLY VSRFVSKALQ NRRKDTADCS SSPDMSPPVP
HKPADLEFAK AEA
//
