ID F4JWL8_ARATH Unreviewed; 900 AA.
AC F4JWL8;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AED92543.1};
GN Name=BAR1 {ECO:0000313|TAIR:AT5G18360};
GN OrderedLocusNames=At5g18360 {ECO:0000313|EMBL:AED92543.1};
GN ORFNames=F20L16.80 {ECO:0000313|EMBL:AED92543.1}, F20L16_80
GN {ECO:0000313|EMBL:AED92543.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AED92543.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AED92543.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130714; DOI=10.1038/35048507;
RG Kazusa DNA Research Institute;
RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG European Union Arabidopsis Genome Sequencing Consortium;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., Entian K.D.,
RA Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., McCullagh B.,
RA Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H.,
RA Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S.,
RA Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J.,
RA Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.W., Bevan M., Fransz P.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; CP002688; AED92543.1; -; Genomic_DNA.
DR RefSeq; NP_197337.1; NM_121841.2.
DR AlphaFoldDB; F4JWL8; -.
DR SMR; F4JWL8; -.
DR STRING; 3702.F4JWL8; -.
DR PaxDb; 3702-AT5G18360-1; -.
DR EnsemblPlants; AT5G18360.1; AT5G18360.1; AT5G18360.
DR GeneID; 831954; -.
DR Gramene; AT5G18360.1; AT5G18360.1; AT5G18360.
DR KEGG; ath:AT5G18360; -.
DR TAIR; AT5G18360; BAR1.
DR eggNOG; ENOG502SUNR; Eukaryota.
DR HOGENOM; CLU_001561_2_1_1; -.
DR InParanoid; F4JWL8; -.
DR OMA; ITRHCKL; -.
DR OrthoDB; 378182at2759; -.
DR PhylomeDB; F4JWL8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4JWL8; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF275; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 14..175
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 900 AA; 102289 MW; 3D4306E39B9CB24F CRC64;
MEESSSLSLQ SCNWRHHVFP SFSGKDVRRT FLSHLLKEFR RKGIRTFIDN DIKRSQMISS
ELVRAIRESR IAVVVLSRTY ASSSWCLNEL VEIKKVSQMI MPVFYEVDPS DVRKRTGEFG
KAFEEACERQ PDEEVKQKWR EALVYIANIA GESSQNWDNE ADLIDKIAMS ISYELNSTLS
RDSYNLVGID NHMRELDSLL CLESTEVKMV GIWGPAGIGK TTIARALFNR LSENFQHTIF
MENVKGSSRT SELDAYGFQL RLQEQFLSEV IDHKHMKIHD LGLVKERLQD LKVLVVLDDV
DKLEQLDALV KQSQWFGSGS RIIVTTENKQ LLRAHGITCI YELGFPSRSD SLQIFCQYAF
GESSAPDGCI ELATEITKLA GYLPLALKVL GSSLRGMSKD EQKSALPRLR TSLNEDIRNV
LRVGYDGIHD KDKVIFLHIA CLFNGENVDY VKQILASSGL DVTFGLQVLT SRSLIHISRC
NRTITMHNLL EQLGREIVCE QSIAEPGKRQ FLMDASEIYD VLADNTGTGA VLGISLDISK
INELFLNERA FGGMHNLLFL RFYKSSSSKD QPELHLPRGL DYLPRKLRLL HWDAFPMTSM
PLSFCPQFLV VINIRESQLE KLWEGTQPLR SLKQMDLSKS ENLKEIPDLS KAVNIEELCL
SYCGSLVMLP SSIKNLNKLV VLDMKYCSKL EIIPCNMDLE SLSILNLDGC SRLESFPEIS
SKIGFLSLSE TAIEEIPTTV ASWPCLAALD MSGCKNLKTF PCLPKTIEWL DLSRTEIEEV
PLWIDKLSKL NKLLMNSCMK LRSISSGIST LEHIKTLDFL GCKNIVSFPV EIFESSRFCH
NLVMEMRNIQ NPDLPRPFYF KNNYIDTIPD CITRHCKLPF LNSSGSISSK IENDFIWFDK
//
