ID F4MHI3_HUMAN Unreviewed; 1014 AA.
AC F4MHI3;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(27) demethylase {ECO:0000256|ARBA:ARBA00034525};
DE EC=1.14.11.68 {ECO:0000256|ARBA:ARBA00034525};
GN Name=UTY {ECO:0000313|EMBL:ABS19060.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS19060.1};
RN [1] {ECO:0000313|EMBL:ABS19060.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21329462; DOI=10.1089/omi.2010.0107;
RA Laaser I., Theis F.J., de Angelis M.H., Kolb H.J., Adamski J.;
RT "Huge splicing frequency in human Y chromosomal UTY gene.";
RL OMICS 15:141-154(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-
CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224,
CC Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.68; Evidence={ECO:0000256|ARBA:ARBA00034421};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the UTX family. {ECO:0000256|ARBA:ARBA00034483}.
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DR EMBL; EF685339; ABS19060.1; -; mRNA.
DR PeptideAtlas; F4MHI3; -.
DR ChiTaRS; UTY; human.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.58.1370; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14017:SF25; HISTONE DEMETHYLASE UTY; 1.
DR PANTHER; PTHR14017; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 90..123
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 127..160
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 519..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..851
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 177
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:ABS19060.1"
SQ SEQUENCE 1014 AA; 111327 MW; FBF89EFC131D687E CRC64;
MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH
EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ
ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEXHLRL GLMFKVDTDY
KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA
TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGSV LYQQQNQPMD
ALQAYICAVQ LDHGHAAAWM DLGTLYESCN QPQDAIKCYL NAARSKRCSN TSXLAARIKF
LQNGSDNWNG GQSLSHHPVQ QVYSLCLTPQ KLQHLEQLRA NRDNLNPAQK HQLEQLESQF
VLMQQMRHKE XAQVRTTGIH NGAITDSSLP TNSVSNRQPH GALTRVSSVS QPGVRPACVE
KLLSSGAFSA GCIPCGTSKI LGSTDTILLG SNCIAGSESN GNVPYLQQNT HTLPHNHTDL
NSSTEEPWRK QLSNSAQGLH KSQSSCLSGP NEEQPLFSTG SAQYHQATST GIKKANEHLT
LPSNSVPQGD ADSHLSCHTA TSGGQQGIMX TKESKPSKNR SLVPETSRHT GDTSNGCADV
KGLSNHVHQL IADAVSSPNH GDSPNLLIAD NPQLSALLIG KANGNVGTGT CDKVNNIHPA
VHTKTDHSVA SSPXSAISTA TPSPKSTEQR SINSVTSLNS PHSGLHTVNG EGLGKSQSST
KVDLPLASHR STSQILPSMS VSICPSSTEV LKACRNPGKN GLSNSXILLD KCPPPRPPTS
PYPPLPKDKL NPPTPSIYLE NKRDAFFPPL HQFCTNPKNP VTVIRGLAGA LKLDLGLFST
KTLVEANNEH MVEVRTQLLQ PADENWDPTG TKKIWRCESN RSHTTIAKYA QYQASSFQES
LREENEKRTQ HKDHSDNEST SSENSGRRRK GPFKTIKFGT NIDLSDNKNN LCLS
//
