ID F4MP30_MYCML Unreviewed; 282 AA.
AC F4MP30;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Release factor glutamine methyltransferase {ECO:0000256|HAMAP-Rule:MF_02126};
DE Short=RF MTase {ECO:0000256|HAMAP-Rule:MF_02126};
DE EC=2.1.1.297 {ECO:0000256|HAMAP-Rule:MF_02126};
DE AltName: Full=N5-glutamine methyltransferase PrmC {ECO:0000256|HAMAP-Rule:MF_02126};
DE AltName: Full=Protein-(glutamine-N5) MTase PrmC {ECO:0000256|HAMAP-Rule:MF_02126};
DE AltName: Full=Protein-glutamine N-methyltransferase PrmC {ECO:0000256|HAMAP-Rule:MF_02126};
GN Name=hemK {ECO:0000313|EMBL:CBW53862.1};
GN Synonyms=prmC {ECO:0000256|HAMAP-Rule:MF_02126};
GN ORFNames=MLC_1340 {ECO:0000313|EMBL:CBW53862.1};
OS Mycoplasma mycoides subsp. capri LC str. 95010.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=862259 {ECO:0000313|EMBL:CBW53862.1, ECO:0000313|Proteomes:UP000010103};
RN [1] {ECO:0000313|EMBL:CBW53862.1, ECO:0000313|Proteomes:UP000010103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=95010 {ECO:0000313|EMBL:CBW53862.1,
RC ECO:0000313|Proteomes:UP000010103};
RA Thiaucourt F., Manso-Silvan L., Salah W., Barbe V., Berger A., Jacob D.,
RA Breton M., Dupuy V., Lomenech A.M., Blanchard A., Sirand-Pugnet P.;
RT "Mycoplasma mycoides, from "mycoides Small Colony" to "capri". A
RT microevolutionary perspective.";
RL BMC Genomics 0:0-0(2011).
RN [2] {ECO:0000313|Proteomes:UP000010103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=95010 {ECO:0000313|Proteomes:UP000010103};
RX PubMed=21324191; DOI=10.1186/1471-2164-12-114;
RA Thiaucourt F., Manso-Silvan L., Salah W., Barbe V., Berger A., Jacob D.,
RA Breton M., Dupuy V., Lomenech A.M., Blanchard A., Sirand-Pugnet P.;
RT "Mycoplasma mycoides, from "mycoides Small Colony" to "capri". A
RT microevolutionary perspective.";
RL BMC Genomics 12:114-114(2011).
RN [3] {ECO:0000313|Proteomes:UP000010103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=95010 {ECO:0000313|Proteomes:UP000010103};
RA Thiaucourt F., Manso-Silvan L., Salah W., Barbe V., Berger A., Jacob D.,
RA Breton M., Dupuy V., Lomenech A.M., Blanchard A., Sirand-Pugnet P.;
RT "Mycoplasma mycoides, from mycoides Small Colony to capri. A
RT microevolutionary perspective.";
RL BMC Genomics 12:0-0(2011).
CC -!- FUNCTION: Methylates the class 1 translation termination release
CC factors RF1/PrfA and RF2/PrfB on the glutamine residue of the
CC universally conserved GGQ motif. {ECO:0000256|HAMAP-Rule:MF_02126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61891; EC=2.1.1.297;
CC Evidence={ECO:0000256|ARBA:ARBA00000932, ECO:0000256|HAMAP-
CC Rule:MF_02126};
CC -!- SIMILARITY: Belongs to the protein N5-glutamine methyltransferase
CC family. PrmC subfamily. {ECO:0000256|HAMAP-Rule:MF_02126}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_02126}.
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DR EMBL; FQ377874; CBW53862.1; -; Genomic_DNA.
DR RefSeq; WP_013729288.1; NC_015431.1.
DR AlphaFoldDB; F4MP30; -.
DR KEGG; mml:MLC_1340; -.
DR HOGENOM; CLU_018398_3_2_14; -.
DR OrthoDB; 9800643at2; -.
DR Proteomes; UP000010103; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0102559; F:protein-(glutamine-N5) methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0036009; F:protein-glutamine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_02126; RF_methyltr_PrmC; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR040758; PrmC_N.
DR InterPro; IPR019874; Release_fac_Glu-N5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 1.
DR NCBIfam; TIGR03534; RF_mod_PrmC; 1.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF17827; PrmC_N; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_02126};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_02126};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_02126}.
FT DOMAIN 13..72
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 107..194
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
FT BINDING 141
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02126"
FT BINDING 186..189
FT /ligand="substrate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02126"
FT BINDING 186
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02126"
SQ SEQUENCE 282 AA; 33079 MW; C0320EBA249DDE87 CRC64;
MNNTIFNVLN KIKNTNISLN KADVYHILEH IINKDYQWII SNLDHKLTKK QIYKIDQIFD
LLKQNYPLAY ILKSKYFYSN NFFINKDVLI PRNESELIID HVSEFVKNNN DLLIVDLCTG
SGCLGISCAL LNDQNKVILT DISYKALKVA NKNIKKFNLT NTSCLNGNFI DVLIKNNLKA
NLIICNPPYI DINDQNIDKN VIEFEPSIAL FAPNKGLYFY EILIKNIDKI VDTNKNFLIV
LEFGWLQKDS IEQLLMNNCL KYKWEFKKDY NDYWRNLIIK NF
//