ID   F4PEA4_BATDJ            Unreviewed;      1076 AA.
AC   F4PEA4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=BATDEDRAFT_92569 {ECO:0000313|EMBL:EGF76522.1};
OS   Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid
OS   fungus).
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC   Rhizophydiales incertae sedis; Batrachochytrium.
OX   NCBI_TaxID=684364 {ECO:0000313|EMBL:EGF76522.1, ECO:0000313|Proteomes:UP000007241};
RN   [1] {ECO:0000313|EMBL:EGF76522.1, ECO:0000313|Proteomes:UP000007241}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAM81 / FGSC 10211 {ECO:0000313|Proteomes:UP000007241};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Kuo A., Salamov A., Schmutz J., Lucas S., Pitluck S., Rosenblum E.,
RA   Stajich J., Eisen M., Grigoriev I.V.;
RT   "The draft genome of Batrachochytrium dendrobatidis.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; GL882896; EGF76522.1; -; Genomic_DNA.
DR   RefSeq; XP_006682897.1; XM_006682834.1.
DR   AlphaFoldDB; F4PEA4; -.
DR   STRING; 684364.F4PEA4; -.
DR   GeneID; 18244673; -.
DR   HOGENOM; CLU_005943_1_0_1; -.
DR   InParanoid; F4PEA4; -.
DR   OMA; FSFMPEF; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000007241; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007241};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          74..298
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          619..1028
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1076 AA;  117728 MW;  863D9F9E7C1A481F CRC64;
     MALESMGLEL AIAKALADGS AVIGTVRPGM DLSVAALSTT TANKSDSTPV PVTTGVDDII
     NELNNGRSSL LKLIECLGPI LTHAEPFQRA SGVALLSTVI SQTETSKISA QSATVLSQFY
     LSRLDDQPSV EPVLNGLLAM VSLSVLSKEE KTAIPARIFS ELNVQSFQQS VRQTVFRLFA
     KLFETNLDGL HELGSEFVFG FIHAMDGEKD PRILILAFRI AQLIIKHLDF SKHAEDLFEV
     VFCYFPITFR PIPGDPYGVT AEDLKHELCA TVAATPLFAP FAVPVLLEKL SSDSAAAKVT
     HRLSFHTFVF YNAIHNIDFC VLKRDAMDAV SACAPVYEGA SFSPYIDAFW DALKKEIVSP
     VEPANELSSL MAIRALVKSL STAISISQKR QSPLEKMIDI ILKDCLENLA DPDLKFAKPC
     GKIMMSAASA SEPACNIIVE KALPVILNAL SNEDAPSKRK TLADVLGDFL VAGRSVYSSK
     NGTSDDLMQT PLKLYCEQLF DFFMPCALSD LYVPLKLSSL RGLTEMLLSR NLLGAKEECA
     VLELVLSWML EDPNTQIHSV ALETITSISA EIPDLVQNVV LEPLLNALKA AQTEFNVLKM
     ESALVSCFAL SKNKQMRSVI LSALIDIFVS AATSTLESHP NMPYILAYER RTLQIVAEIL
     LESSTQPIML TLDQTHTCEL IFKLVLTSVN TAPAMDETMK NEIVCLVAKV VALMIRSLDV
     PHQSQIIKEL KHSFQSFNSP VVLTDPVYAY LTAAVMTNVS SKTPFDILDL EVYSNELINM
     SIQLDGLYAL ATSKILASIV NKGHGVQGID AFVTHFCQTK CDSALVAVHC TLPQRQTILK
     VYSWIAKALV VKADPRGYQM TLQILGLLSN ADLGLAAADA INVLISDDSQ GVLTKMAGAN
     IKMLYKQRLY NYCLPIVSSG FQVASDGSRN AYLYSLSHLL HNVSKGVLLS ELPKLLPMLL
     HSLTLNETTL KLGTLDTLQQ MVKDAPAVLE SQISSIMTLL LPMCLFKNAN QGNDARVRVS
     AIAILGLLMS WVNYTVLHPF KPRVLQELAY ALDDPKRVVR KEAANTRSIW FMPQPT
//