ID   F4RZX9_MELLP            Unreviewed;      1132 AA.
AC   F4RZX9;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   ORFNames=MELLADRAFT_117644 {ECO:0000313|EMBL:EGG02080.1};
OS   Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf
OS   rust fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX   NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN   [1] {ECO:0000313|Proteomes:UP000001072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX   PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA   Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA   Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA   Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA   Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA   Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA   Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA   Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA   Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA   Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA   Grigoriev I.V., Szabo L.J., Martin F.;
RT   "Obligate biotrophy features unraveled by the genomic analysis of rust
RT   fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
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DR   EMBL; GL883133; EGG02080.1; -; Genomic_DNA.
DR   RefSeq; XP_007414617.1; XM_007414555.1.
DR   AlphaFoldDB; F4RZX9; -.
DR   STRING; 747676.F4RZX9; -.
DR   EnsemblFungi; EGG02080; EGG02080; MELLADRAFT_117644.
DR   GeneID; 18926060; -.
DR   KEGG; mlr:MELLADRAFT_117644; -.
DR   VEuPathDB; FungiDB:MELLADRAFT_117644; -.
DR   eggNOG; KOG1453; Eukaryota.
DR   HOGENOM; CLU_278867_0_0_1; -.
DR   InParanoid; F4RZX9; -.
DR   OrthoDB; 1431132at2759; -.
DR   Proteomes; UP000001072; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR   PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001072}.
FT   DOMAIN          338..556
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          60..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1111..1132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1117..1132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1132 AA;  126086 MW;  5482A769DC5F1158 CRC64;
     MMRPQSNGAR KLFNSEWICL IRLLDKVYEH LTTKLLSIRE REREMSLISR RNQFYYQSNQ
     LNNSSNSLDS SHHPYQSQYS RDTNPKIVNR SRSVTFKDGS ALHDHHQIIN HRNRNLSLTE
     RTTRVVEFPQ HSTHQTQHHY QQDYYQNKEN QSECLKELDS NQTPINTNTH LKRHRRKSRS
     DLQLKSNSNS ISPNSHANPS ITSSPPASIT PSSNNLATIQ FPIRLDTRTE LISILDSILG
     SHRLSTLVNL DHLRNEPNDT PTISPSSNPT SPQLSVQSPT PSATDTSQSK GLFKRLGWRT
     RAITLASIRP STATTSKLTE DPPSSQRDSI KSFRLFGAPL SETACASCVT IIGGQKHRLP
     ILVFKTVEEI YTRGLGIPGL FRTKGNPLRI ESLIKAFETS PSYGDLVALD REGVFDLCDL
     LRNFLWSLPQ PLLEPDLGEL FWTTCVDEDG PEKLPIATRV TIAQVIFRLL PTRSFSLLVY
     LIAFLSQIPL SPGNQLSLPM ISQIFGPALL APRKVGIVGL GIDGHSALLE SNMPKEISRR
     AVNGLAWLQS NWNQITDGLL DERIRYPPPQ ASLPSVPTSP RALTIVEEAS FECDSEGQAE
     TEVEKIISSD KKTESQPEIE TESTIVALQP RKANDSSRSL SVSSSAKKPL DPRPTSCSQS
     LIDYPQSTAR MSCGNLSHHL DPSLSTMSDS QKTIDPPRSL SASSATKKHS NPRPISTSQS
     LFNYTQSKAS SSLSDVLHHP EACSSSIPEH RETLALPRSV STSSVPKLSE TTRLFSPQSL
     IEDFGKTESS PALASHLRRD SETSNASITL SSASVLSTLL TPIQGNLSRS RQERFPSMVL
     EAETEPIFVT SPPAIHTSQS TAPTSFGSSL SNAQSIVDQY EAHGPEQLRK IIDSFKAQDH
     RERRVSTCTS RCESCSSVLP GDLKRYSIGA TWTASDSPKL CSCPINIRPR IPISTRTKRT
     IPTLSTRKTT QAVKRIGVAE EDSSEEDSDP LLALSEMMRS KNGMIRAQAE TIKAQAELLV
     ESENRLAAQT AHSRTEELDE YFIPLLKSIE SLNKENRKRI ENELIRLRFT WEMERKDYEE
     EKVKIKEKLL NTLQDYEKVC DQLSVIRRAI GEEPNHSHDN GNGQSSSSSS SL
//