ID F4T7I8_ECOLX Unreviewed; 1309 AA.
AC F4T7I8;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Serine protease EspC (EPEC-secreted proteinC) {ECO:0000313|EMBL:EGI13265.1};
GN ORFNames=ECIG_04612 {ECO:0000313|EMBL:EGI13265.1};
OS Escherichia coli M605.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=656417 {ECO:0000313|EMBL:EGI13265.1, ECO:0000313|Proteomes:UP000004710};
RN [1] {ECO:0000313|EMBL:EGI13265.1, ECO:0000313|Proteomes:UP000004710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M605 {ECO:0000313|EMBL:EGI13265.1,
RC ECO:0000313|Proteomes:UP000004710};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli M605.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004571}. Cell surface
CC {ECO:0000256|ARBA:ARBA00004241}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Periplasm
CC {ECO:0000256|ARBA:ARBA00004418}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; GL883931; EGI13265.1; -; Genomic_DNA.
DR RefSeq; WP_001080128.1; NZ_GL883931.1.
DR HOGENOM; CLU_000723_0_0_6; -.
DR Proteomes; UP000004710; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01343; PL1_Passenger_AT; 1.
DR Gene3D; 2.160.20.20; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR InterPro; IPR005546; Autotransporte_beta.
DR InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR InterPro; IPR012332; Autotransporter_pectin_lyase_C.
DR InterPro; IPR024973; ESPR.
DR InterPro; IPR006315; OM_autotransptr_brl_dom.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000710; Peptidase_S6.
DR InterPro; IPR030396; Peptidase_S6_dom.
DR NCBIfam; TIGR01414; autotrans_barl; 1.
DR Pfam; PF03797; Autotransporter; 1.
DR Pfam; PF13018; ESPR; 1.
DR Pfam; PF02395; Peptidase_S6; 1.
DR SMART; SM00869; Autotransporter; 1.
DR SUPFAM; SSF103515; Autotransporter; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51208; AUTOTRANSPORTER; 1.
DR PROSITE; PS51691; PEPTIDASE_S6; 1.
PE 4: Predicted;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EGI13265.1};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 34..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..296
FT /note="Peptidase S6"
FT /evidence="ECO:0000259|PROSITE:PS51691"
FT DOMAIN 1043..1309
FT /note="Autotransporter"
FT /evidence="ECO:0000259|PROSITE:PS51208"
SQ SEQUENCE 1309 AA; 141481 MW; 10F85BA40A48DF5B CRC64;
MNRIYSLKYC HLTQGLIAVS ELASRVSSKT GRKLLAIFIV SALSYGAAEY ACAAQMDTRN
FWIRDYLDLA QNKGAFQPGA YGVKTPLKNG GEFSFPEVTI PDFSPVSAKG ATTAIGNAYS
VTASHNGTIH HAIKTQTWGQ SDYHYVDRVT KGDFAVQRLD KFVVETAGAT EHADFNLSAA
EALERYGIEF NGKKQIIGFR VGAGATGVTS YGVGQTYNPL LRSASMFQLN WNNMYASNNT
GGFYNEVTGG DSGSGFYLYD NQKKKWVILG TLTGKVFSSK DTWAFFARYD QNTVDILKNT
FTQEVNLNGQ KMTVNNKNIA INDKITAIEL TKSNKNKDLK FHGGGSIELT DNLNSGTGGL
IFDEGQHYSV IGKDKAYKGA GVEIGKDTVV DWSVKGEAND NLHKTGAGTL NVNVAQGNNL
KTGDGTVFLN AEKAFNAIYV ASGRGTVKLG QADALDKNSD YRGIYFTSRG GTLDLNGFSQ
SFKKIAATDV GTIITNTSDK TATLSLQNPS RYVYHGSITG NTNIEHTGTQ KSADSSLIID
GNINTRNDIT VRNSQLRLQG HATSHAIFRE GPRHCYVPGV LCDKDYVTDF ARLESEANKK
NNSAYKTNNQ VASFDQPDWE TRHFRFKTLN LENSEFTTAR NSVVEGDIVA SNSTLKLGGD
VPVFIDMYDG INITGNGFGF RQDVREGRSA DDGSSSYTGK ITLQKGSTLD INNRFIGGIE
AHDSKVNVTS PDALLQNSGV FVNSTLSVRD GGHLTAQKGL YSDGRVQIGK KGTLSLSGTP
ENGADNTWMP VLTYMTEGYD LTGDNATLNI SQQAHVSGDV HATSSSSIRI GSENPGSVSS
SVSPVLAAGL FSGYNAAYYG AITGGKGNVS MNNGLWQLTG DSDINSLTTR NSRVQSEENG
AFRTLTVKTL DATGSDFVLR TDLKDADKIS ITEKASGSDN TLNVSFMKNP SPGQSLNIPL
VSAPAGTSGD IFKAGTRVTG FSRVTPTLRV DTTGGSTKWI LDGFRTEADK AAAAKANSFM
NAGYKSFMTE VNNLNKRMGE LRDTNGDAGA WARIMNGAGS ADGGYSDNYT HVQVGFDKKH
ALDGVDLFTG VTMTYTDSSA DSDAFSGKTK SVGGGLYASA LFNSGAYIDL IGKYIHHDND
YTGNFAGLGT KHYGTHSWYA GAETGYRYHL TEDTFIEPQA ELVYGAVSGK TFRWKDGEMD
LSMKNKDFSP LIGRTGIELG KTFRGKDWSV TARAGTSWQF DLLNNGETVL RDASGEKRIK
GEKDSRMLFN VGMNAQIKDN MRFGLEFEKS AFGKYNVDNA INANFRYMF
//
