ID F4V5J6_ECOLX Unreviewed; 567 AA.
AC F4V5J6;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Type 3 secretion system secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Short=T3SS secretin {ECO:0000256|HAMAP-Rule:MF_02219};
DE Flags: Precursor;
GN Name=sctC {ECO:0000256|HAMAP-Rule:MF_02219};
GN ORFNames=ECNG_00898 {ECO:0000313|EMBL:EGI39837.1};
OS Escherichia coli TA280.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=656444 {ECO:0000313|EMBL:EGI39837.1, ECO:0000313|Proteomes:UP000004877};
RN [1] {ECO:0000313|EMBL:EGI39837.1, ECO:0000313|Proteomes:UP000004877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TA280 {ECO:0000313|EMBL:EGI39837.1,
RC ECO:0000313|Proteomes:UP000004877};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli TA280.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the type III secretion system (T3SS), also
CC called injectisome, which is used to inject bacterial effector proteins
CC into eukaryotic host cells. Forms a ring-shaped multimeric structure
CC with an apparent central pore in the outer membrane.
CC {ECO:0000256|HAMAP-Rule:MF_02219}.
CC -!- SUBUNIT: The core secretion machinery of the T3SS is composed of
CC approximately 20 different proteins, including cytoplasmic components,
CC a base, an export apparatus and a needle. This subunit is part of the
CC base, which anchors the injectisome in the bacterial cell envelope.
CC Forms a stable homooligomeric complex. {ECO:0000256|HAMAP-
CC Rule:MF_02219}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004442, ECO:0000256|HAMAP-Rule:MF_02219,
CC ECO:0000256|RuleBase:RU004004}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the bacterial secretin family. T3SS SctC
CC subfamily. {ECO:0000256|ARBA:ARBA00007032, ECO:0000256|HAMAP-
CC Rule:MF_02219}.
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DR EMBL; GL884370; EGI39837.1; -; Genomic_DNA.
DR AlphaFoldDB; F4V5J6; -.
DR HOGENOM; CLU_022474_3_0_6; -.
DR Proteomes; UP000004877; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030257; C:type III protein secretion system complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.120; -; 2.
DR Gene3D; 3.55.50.30; -; 1.
DR HAMAP; MF_02219; Type_III_secretin; 1.
DR InterPro; IPR005644; NolW-like.
DR InterPro; IPR038591; NolW-like_sf.
DR InterPro; IPR004846; T2SS/T3SS_dom.
DR InterPro; IPR004845; T2SS_GspD_CS.
DR InterPro; IPR049034; T3S_SPI-1_N0.
DR InterPro; IPR003522; T3SS_OM_pore_YscC.
DR NCBIfam; TIGR02516; type_III_yscC; 1.
DR PANTHER; PTHR30332; PROBABLE GENERAL SECRETION PATHWAY PROTEIN D; 1.
DR PANTHER; PTHR30332:SF5; SPI-1 TYPE 3 SECRETION SYSTEM SECRETIN; 1.
DR Pfam; PF00263; Secretin; 1.
DR Pfam; PF03958; Secretin_N; 1.
DR Pfam; PF21304; T3S_SPI-1_N0; 1.
DR PRINTS; PR01337; TYPE3OMGPROT.
DR PROSITE; PS00875; T2SP_D; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_02219};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02219};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_02219};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_02219};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_02219};
KW Transport {ECO:0000256|HAMAP-Rule:MF_02219, ECO:0000256|RuleBase:RU004004};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT CHAIN 29..567
FT /note="Type 3 secretion system secretin"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02219"
FT /id="PRO_5026396660"
FT DOMAIN 34..102
FT /note="SPI-1 type 3 secretion system secretin N0"
FT /evidence="ECO:0000259|Pfam:PF21304"
FT DOMAIN 180..305
FT /note="NolW-like"
FT /evidence="ECO:0000259|Pfam:PF03958"
FT DOMAIN 362..517
FT /note="Type II/III secretion system secretin-like"
FT /evidence="ECO:0000259|Pfam:PF00263"
SQ SEQUENCE 567 AA; 62754 MW; 6D7924B3D97459C4 CRC64;
MKIKLRITII LISALCIFNG LLTPGAYAAT ANGYVANKEN LRSFFETVSS YAGKPTIVSK
LAMKKQISGN FDLTEPYALI ERLSAQMGLI WYDDGKAIYI YDSSEMRNAL INLRKVSTNE
FNNFLKKSGL YNSRYEIKGG GNGTFYVSGP PVYVDLVVNA AKLMEQNSDG IEIGRNKVGI
IHLVNTFVND RTYELRGEKI VIPGMAKVLS TLLNNNIKQS TGVNVLSEIS SRQQLKNVSR
MPPFPGAEED DDLQVEKIIS TAGAPETDDI QIIAYPDTNS LLVKGTVSQV DFIEKLVATL
DIPKRHIELS LWIIDIDKTD LEQLGADWSG TIKIGSSLSA SFNNSGSIST LDGTQFIATI
QALAQKRRAA VVARPVVLTQ ENIPAIFDNN RTFYTKLVGE RTAELDEVTY GTMISVLPRF
ASRNQIELLL NIEDGNEINS DKTNVDDLPQ VGRTLISTIA RVPQGKSLLI GGYTRDTNTY
ESRKIPILGS IPFIGKLFGY EGTNANNIVR VFLIEPREID ERMMNNANEA AVDARAITQQ
MAKNKEINDE LLQKWIKTYL NREVVGG
//
