ID   F4V6Q1_ECOLX            Unreviewed;       226 AA.
AC   F4V6Q1;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Semialdehyde dehydrogenase NAD-binding domain-containing protein {ECO:0000259|SMART:SM00859};
GN   ORFNames=ECNG_03709 {ECO:0000313|EMBL:EGI39525.1};
OS   Escherichia coli TA280.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=656444 {ECO:0000313|EMBL:EGI39525.1, ECO:0000313|Proteomes:UP000004877};
RN   [1] {ECO:0000313|EMBL:EGI39525.1, ECO:0000313|Proteomes:UP000004877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TA280 {ECO:0000313|EMBL:EGI39525.1,
RC   ECO:0000313|Proteomes:UP000004877};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli TA280.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL884371; EGI39525.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4V6Q1; -.
DR   HOGENOM; CLU_071330_2_0_6; -.
DR   Proteomes; UP000004877; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   PANTHER; PTHR14097; OXIDOREDUCTASE HTATIP2; 1.
DR   PANTHER; PTHR14097:SF7; OXIDOREDUCTASE HTATIP2; 1.
DR   Pfam; PF13460; NAD_binding_10; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          18..118
FT                   /note="Semialdehyde dehydrogenase NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00859"
SQ   SEQUENCE   226 AA;  24803 MW;  B2B32689318EE641 CRC64;
     MSRGAQGRQF CKGAKMSQVL ITGATGLVGG HLLRMLINEP KVNAIAAPTR RPLGDMPGVF
     NPHDPQLTDA LAQVTDPIDI VFCCLGTTRR EAGSKEAFIH ADYTLVVDTA LTGRRLGAQH
     MLVVSAMGAN AHSPFFYNRV KGEMEEALIA QNWPKLTIAR PSMLLGDRSK QRMNETLFAP
     LFRLLPGNWK SIDARDVARV MLAEAMRPEH EGVTILSSSE LRKRAE
//