ID F4VD98_ECOLX Unreviewed; 97 AA.
AC F4VD98;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Negative regulator of flagellin synthesis {ECO:0000256|ARBA:ARBA00017823};
DE AltName: Full=Anti-sigma-28 factor {ECO:0000256|ARBA:ARBA00030117};
GN ORFNames=ECPG_02270 {ECO:0000313|EMBL:EGI46849.1};
OS Escherichia coli H591.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=656408 {ECO:0000313|EMBL:EGI46849.1, ECO:0000313|Proteomes:UP000004681};
RN [1] {ECO:0000313|EMBL:EGI46849.1, ECO:0000313|Proteomes:UP000004681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H591 {ECO:0000313|EMBL:EGI46849.1,
RC ECO:0000313|Proteomes:UP000004681};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Escherichia coli H591.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the coupling of flagellin expression to
CC flagellar assembly by preventing expression of the flagellin genes when
CC a component of the middle class of proteins is defective. It negatively
CC regulates flagellar genes by inhibiting the activity of FliA by
CC directly binding to FliA. {ECO:0000256|ARBA:ARBA00024739}.
CC -!- SIMILARITY: Belongs to the FlgM family.
CC {ECO:0000256|ARBA:ARBA00005322}.
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DR EMBL; GL884434; EGI46849.1; -; Genomic_DNA.
DR RefSeq; WP_000020880.1; NZ_GL884434.1.
DR AlphaFoldDB; F4VD98; -.
DR SMR; F4VD98; -.
DR GeneID; 75203658; -.
DR HOGENOM; CLU_149304_2_2_6; -.
DR Proteomes; UP000004681; Unassembled WGS sequence.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR035890; Anti-sigma-28_factor_FlgM_sf.
DR InterPro; IPR007412; FlgM.
DR InterPro; IPR031316; FlgM_C.
DR NCBIfam; TIGR03824; FlgM_jcvi; 1.
DR Pfam; PF04316; FlgM; 1.
DR SUPFAM; SSF101498; Anti-sigma factor FlgM; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW Cell projection {ECO:0000313|EMBL:EGI46849.1};
KW Cilium {ECO:0000313|EMBL:EGI46849.1};
KW Flagellum {ECO:0000313|EMBL:EGI46849.1};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 40..88
FT /note="Anti-sigma-28 factor FlgM C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04316"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 97 AA; 10341 MW; 367D6F63324BF75D CRC64;
MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL MQPGSSDINL
ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
//
