ID   F4W9U9_ACREC            Unreviewed;       575 AA.
AC   F4W9U9;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 {ECO:0000313|EMBL:EGI69085.1};
GN   ORFNames=G5I_02257 {ECO:0000313|EMBL:EGI69085.1};
OS   Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS   echinatior).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Acromyrmex.
OX   NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN   [1] {ECO:0000313|EMBL:EGI69085.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nygaard S., Zhang G.;
RT   "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT   adaptations to social evolution and fungus farming.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; GL888033; EGI69085.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4W9U9; -.
DR   EnsemblMetazoa; XM_011070721.1; XP_011069023.1; LOC105154919.
DR   eggNOG; KOG0498; Eukaryota.
DR   InParanoid; F4W9U9; -.
DR   Proteomes; UP000007755; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR   PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..575
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003318434"
FT   TRANSMEM        27..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          366..482
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
SQ   SEQUENCE   575 AA;  66395 MW;  923F454DDF7D76AA CRC64;
     MLLLLVANLI ILPVAISFFN DDLSTRWIAF NCLSDTIFLI DIVVNFRTGI MQQDNAEQVI
     LDPKLIAKHY LRTWFFLDLI SSIPLDYIFL IFNQFQDFSE SFQILHAGRA LRILRLAKLL
     SLVRLLRLSR LVRYVSQWEE VYILQNLQKK RTERRGRLSS DNMTKKKSGF SKSELIFKFL
     NMASVFMRIF NLICMMLLIG HWSGCLQFLV PMLQGFPSNS WVAINELQDS FWLEQYSWAL
     FKAMSHMLCI GYGRFPPQSL TDMWLTMLSM ISGATCYALF LGHATNLIQS LDSSRRQYRE
     KVKQVEEYMA YRKLPREMRQ RITEYFEHRY QGKFFDEELI LGELSEKLRE DVINYNCRSL
     VASVPFFANA DSNFVSDVVT KLRYEVFQPG DIIIKEGTIG SKMYFIQEGI VDIVMANGEV
     ATSLSDGSYF GEICLLTNAR RVASVRAETY CNLFSLSVDH FNAVLDQYPL MRRTMESVAA
     ERLNKIGKNP NLVAHREEDL GSESKTINAV VNALAEQAAH ASASEESVHS MELRTLPACL
     LPRPKSENNF ASQELTREGR RIFHKSDTFH KDSYQ
//