ID   F4WL38_ACREC            Unreviewed;       933 AA.
AC   F4WL38;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Ras guanine nucleotide exchange factor E {ECO:0000313|EMBL:EGI65001.1};
GN   ORFNames=G5I_06461 {ECO:0000313|EMBL:EGI65001.1};
OS   Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS   echinatior).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Acromyrmex.
OX   NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN   [1] {ECO:0000313|EMBL:EGI65001.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nygaard S., Zhang G.;
RT   "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT   adaptations to social evolution and fungus farming.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL888207; EGI65001.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4WL38; -.
DR   STRING; 103372.F4WL38; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   InParanoid; F4WL38; -.
DR   Proteomes; UP000007755; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007755}.
FT   DOMAIN          591..819
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   933 AA;  107830 MW;  7771FAB5EBFB7991 CRC64;
     MNASRGTRLS DRSRDNRIRK LLLSEYHEFS EIILVESPFA ETTRNGRGIR QVTLGLTPTK
     LIVAADILQT NPGFFCPSCI DASIESFELV SVYPLEYVTL SVFRRRHRRT LKARFIDSRV
     NYYELGGERR KVSWKIWCEQ VQRLLAYKTN GSSLSETTAA SSSSSSALYL LSSEIEIRSN
     RDARCKRSIF RVWNHYGGAG DYVAPTWTEK NLYLGPRYNE LMNGNYTPVP VRFAGASLED
     LRYELEDRTP RYIACEKSCH SWPCQTKFDG RARFQRAGGL CNVLFARSRN VCHCDYAASC
     KKRRNMFFED DFVEHLENKY GKRQQQYQNE PKGTLKISRF GFGVSEKCNS ELILGPYRGD
     SSYEDVIDAR KLLENGVTIW EDNCRSLKGQ RHPRRYGLSS AAHFFHALGP WSVQPGERES
     VQTLRSPSAV NIRKQPSDPE LRLPVSRRQL TASISCTALT PGGSSIIGAV TRGRVILFWT
     PEYWYRPQAA VAAYRELRHH LASLQNFRRG KEKQSKGKFF YRRKNRISSE NDNIEVAITG
     KSSSLLDRVL SINGARKRDG KTNRNVNVDE GTAQLRRLLR MTLRITMWDL DSTTFAAQLT
     SIDRDLFVRI PTTEIEALMY QRSSRNAPNL GAWIAFSHRI ACLTVSEILA IKQLDMRTRI
     MARFINAADK CFALGNFQSC RSILAGLQAP PIYRLWKSWS YLRTHHASRY ATMERLSKIY
     KSPRCSKYRK IWIVAKRNPP CMPYVGHFLM KVLGLNSLKE IQANFAPFFT KKQLTARIHG
     TSESLSINNN FNDHHSRDDK NVIESKQSLA RRIFTATLTR IKFTAHQNVI DETKSDVWTC
     GQRYLARRFF NRWRVFTLEM KVRSQNKKKL KNADLRRKRV IDIAAWLTDC QRFALGYNFP
     LNSFACEYLL KARYREDREN FFISLMLEPP RTT
//