ID F4WYG6_ACREC Unreviewed; 245 AA.
AC F4WYG6;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=GCS light chain {ECO:0000256|ARBA:ARBA00031732};
DE AltName: Full=Gamma-ECS regulatory subunit {ECO:0000256|ARBA:ARBA00030406};
DE AltName: Full=Gamma-glutamylcysteine synthetase regulatory subunit {ECO:0000256|ARBA:ARBA00032926};
DE AltName: Full=Glutamate--cysteine ligase modifier subunit {ECO:0000256|ARBA:ARBA00031154};
GN ORFNames=G5I_11016 {ECO:0000313|EMBL:EGI60774.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI60774.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from
CC L-cysteine and L-glutamate: step 1/2. {ECO:0000256|ARBA:ARBA00005006}.
CC -!- SUBUNIT: Heterodimer of a catalytic heavy chain and a regulatory light
CC chain. {ECO:0000256|ARBA:ARBA00011532}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC Glutamate--cysteine ligase light chain subfamily.
CC {ECO:0000256|ARBA:ARBA00008612}.
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DR EMBL; GL888441; EGI60774.1; -; Genomic_DNA.
DR RefSeq; XP_011062171.1; XM_011063869.1.
DR AlphaFoldDB; F4WYG6; -.
DR STRING; 103372.F4WYG6; -.
DR EnsemblMetazoa; XM_011063869.1; XP_011062171.1; LOC105150647.
DR GeneID; 105150647; -.
DR KEGG; aec:105150647; -.
DR eggNOG; KOG3023; Eukaryota.
DR InParanoid; F4WYG6; -.
DR OrthoDB; 1706825at2759; -.
DR UniPathway; UPA00142; UER00209.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0006750; P:glutathione biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR032963; Gclm.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR13295; GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR13295:SF4; GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Glutathione biosynthesis {ECO:0000256|ARBA:ARBA00022684};
KW Ligase {ECO:0000313|EMBL:EGI60774.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755}.
FT DOMAIN 61..191
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
SQ SEQUENCE 245 AA; 27547 MW; C6F0CE85EA04FF48 CRC64;
MLSHNLFINT GNILSLSEAK QKASQNSTDE LIETLKIILN GEKSKGDDKT IINGKKDTSL
QDVDRKDLKI TVKVFISSPD VNSLKEALDQ AFETLHTDTI ESLVIAYKSA ESPEDILSSL
KKIWSVVEEY VKVDKLCSVG LSDINTNTFI ELFQWADIKP NIVQINLATC CVVPPALQEF
TKENDIQLLT HSDPCQILPQ EVLENIFGST AYLYWLIRYQ IHLKCRGILS SKGYLLRINK
SNVKS
//
