ID   F4X3X2_ACREC            Unreviewed;       962 AA.
AC   F4X3X2;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:EGI58919.1};
GN   ORFNames=G5I_13035 {ECO:0000313|EMBL:EGI58919.1};
OS   Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS   echinatior).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Acromyrmex.
OX   NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN   [1] {ECO:0000313|EMBL:EGI58919.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nygaard S., Zhang G.;
RT   "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT   adaptations to social evolution and fungus farming.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; GL888624; EGI58919.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4X3X2; -.
DR   STRING; 103372.F4X3X2; -.
DR   MEROPS; M16.A08; -.
DR   eggNOG; KOG0959; Eukaryota.
DR   InParanoid; F4X3X2; -.
DR   Proteomes; UP000007755; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          33..164
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          197..374
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          380..661
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          676..848
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   962 AA;  112902 MW;  0A02AFD27CED762F CRC64;
     MSTERVEKRC DDIIKSQNDD RLYRGLVLTN KMKVILISDP TTDKSAAAMD INVGSMCDPD
     DLPGLAHFCE HMLFLGTKKY PQQNDYNKFL SQNGGMSKAI THLDHTIYYF DVSFEKLKGA
     LDRFAQFFLT PLFTENLIEL ELNAINSEHE KNLADDSQRV NHLIKSSANS HHPFSKFSTG
     NRESLDTIPK QKGINVRNKL LEFYEKYYSA NIMSLSVLGK ESLDELENMV VDLFCEVRNK
     EIQVPTWPEH PFKDEHFRTM WYIVPKTYIR SLNIEFPLPD MHRQSSPEHY VSYLLQHERK
     GSLLSVLRAK KWGNYLKSTQ RAQSARGFSI FNIFIDLTKK GIKHIEDIIL LVFQYINMLK
     LEEPSKWIYD EYRDIDNIKF YFKEKSSPRT HVKFTVRALQ EFPMNEILCA CVNPEWRPDL
     IKKIIGYLTP QNVRIYITAK EYENIADEIE SWYGTKYKKV KVSKKIMDMW NSPGFNDDLK
     LPPKNEFIAT IFDIKPQINV VKFPIILKDT SFVKLWYKKD DEFLVPKAKM IFDFFIPFAH
     VDPLSCNFTY MFINLFRESL NEYTYAANLA GLQWELNSFK YGITLSIDGY DDKQHVLLEK
     IMDRMINFEV DPKRFEILKK KYIWKLTSEG LTFKLLHEHA INYLVNLLEG QQWLREELLE
     ATTYLDVRGF KRHILQLFNK MHIQCLIYGN VTEMEAIDIL ELIEFKLMTG VPNIIPLLEQ
     KLELSREIKL ENGCHFLFEV KNDLYKSSCT IVYYPTGLQS IESNMLLELL AQIIAEPCFN
     TLKTKEQLDY IVLSDIHRSN KAQGLRIIVQ SDKHPQYVEK RINLFLHSML NHISTMTEEQ
     FEENKKALAV RLGKPNRLSA RCILYWNEII NQQCNFDRVN IEAAYLKTIS QQQLLNFFKD
     MAKLVVSVWS LVTATEIVRT KRLNWPATVW RFPQSSHQPS SSSLLVLSWT RSILRDLIEL
     PR
//