ID F4YE02_CERSI Unreviewed; 264 AA.
AC F4YE02;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Frizzled-like protein 4 {ECO:0000313|EMBL:AEB78656.1};
DE Flags: Fragment;
GN Name=FZD4 {ECO:0000313|EMBL:AEB78656.1};
OS Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Ceratotherium.
OX NCBI_TaxID=9807 {ECO:0000313|EMBL:AEB78656.1};
RN [1] {ECO:0000313|EMBL:AEB78656.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21900649; DOI=10.1093/sysbio/syr089;
RA Zhou X., Xu S., Xu J., Chen B., Zhou K., Yang G.;
RT "Phylogenomic analysis resolves the interordinal relationships and rapid
RT diversification of the laurasiatherian mammals.";
RL Syst. Biol. 61:150-164(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU990807; AEB78656.1; -; Genomic_DNA.
DR AlphaFoldDB; F4YE02; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..40
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 98..264
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB78656.1"
FT NON_TER 264
FT /evidence="ECO:0000313|EMBL:AEB78656.1"
SQ SEQUENCE 264 AA; 29962 MW; 83914F39374DD428 CRC64;
LSVKRRCEPV LKEFGFAWPE SLNCSKFPPQ NDHNHMCMEG PGDEEVPLPH KTPIQPGEEC
HSVGANSDQY IWVKRSLNCV LKCGYDAGLY SRSAKEFTDI WMAVWASLCF ISTAFTVLTF
LIDSSRFSYP ERPIIFLSMC YNIYSIAYIV RLTVGRERIS CDFEEAAEPV LIQEGLKNTG
CAIIFLLMYF FGMASSIWWV ILTLTWFLAA GLKWGHEAIE MHSSYFHIAA WAIPAVKTIV
ILIMRLVDAD ELTGLCYVGN QNLD
//
