ID F4ZGT3_9VIRU Unreviewed; 162 AA.
AC F4ZGT3;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Viral ankyrin {ECO:0000313|EMBL:AEE09523.1};
GN ORFNames=CvBV-C14_7 {ECO:0000313|EMBL:AEE09523.1};
OS Cotesia vestalis bracovirus.
OC Viruses; Polydnaviriformidae; Bracoviriform.
OX NCBI_TaxID=449720 {ECO:0000313|EMBL:AEE09523.1};
RN [1] {ECO:0000313|EMBL:AEE09523.1}
RP NUCLEOTIDE SEQUENCE.
RA Chen Y.-F., Gao F., Zheng H.-J., Ye X.-Q., Wei S.-J., Shi M., Chen X.-X.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEE09523.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21470650; DOI=10.1016/j.virol.2011.03.009;
RA Chen Y.F., Gao F., Ye X.Q., Wei S.J., Shi M., Zheng H.J., Chen X.X.;
RT "Deep sequencing of Cotesia vestalis bracovirus reveals the complexity of a
RT polydnavirus genome.";
RL Virology 414:42-50(2011).
CC -!- FUNCTION: Suppresses the host immune response through NF-kappa-B
CC inactivation. Possesses ankyrin repeat domains required for NF-kappa-B
CC binding but lacks the regulatory regions required for dissociation from
CC NF-kappa-B and degradation. Therefore, prevents host NF-kappa-B release
CC and subsequent activation. {ECO:0000256|ARBA:ARBA00037244}.
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DR EMBL; HQ009537; AEE09523.1; -; Genomic_DNA.
DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR46680; NF-KAPPA-B INHIBITOR ALPHA; 1.
DR PANTHER; PTHR46680:SF3; NF-KAPPA-B INHIBITOR CACTUS; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host NF-kappa-B by virus {ECO:0000256|ARBA:ARBA00022863};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 162 AA; 18343 MW; CCC18F7022B2C8E0 CRC64;
MESDMILQML SARSASGGNY FHEACQAGSL ALLLRAAEWM DRPTPSILTV RNYSGEQCTH
IIVKNKDIYA QEMMNIVLNL GADINGQEWL GGFTPLHLCV WERNYELAEW LCRAPGIDLE
ATNYAGQTVY QLALERKDNQ IMEMMKRAGA KCDPLELKNR NE
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