ID   F4ZT61_9NEOB            Unreviewed;       201 AA.
AC   F4ZT61;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AEB38841.1};
OS   Colostethus pratti (Pratt's rocket frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Dendrobatidae; Colostethinae;
OC   Colostethus.
OX   NCBI_TaxID=44368 {ECO:0000313|EMBL:AEB38841.1};
RN   [1] {ECO:0000313|EMBL:AEB38841.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=24A {ECO:0000313|EMBL:AEB38841.1};
RX   PubMed=21444790; DOI=10.1073/pnas.1010952108;
RA   Santos J.C., Cannatella D.C.;
RT   "Phenotypic integration emerges from aposematism and scale in poison
RT   frogs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:6175-6180(2011).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; HQ290607; AEB38841.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4ZT61; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          109..200
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEB38841.1"
FT   NON_TER         201
FT                   /evidence="ECO:0000313|EMBL:AEB38841.1"
SQ   SEQUENCE   201 AA;  22688 MW;  D5E3310BEA1B16D7 CRC64;
     VRGQSGLAYP GLRTHGTLES IGGPMSSSRG GGLPSLTDTF EHVIEELLEE EQSMRQSEEN
     KDSDMYTSRV MLSTQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR RGELSVCDSI
     SEWVTAADKK TAIDMAGQTV TVLEKVPVPK GQLKQYFYET KCNPMGYMKE GCRGIDKRYW
     NSQCRTTQSY VRALTMDSKK K
//