ID   F5A8D6_CRAGI            Unreviewed;       581 AA.
AC   F5A8D6;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Inhibitor of apoptosis protein {ECO:0000313|EMBL:AEB54800.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:AEB54800.1};
RN   [1] {ECO:0000313|EMBL:AEB54800.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21237195; DOI=10.1016/j.dci.2011.01.005;
RA   Zhang L., Li L., Zhang G.;
RT   "Gene discovery, comparative analysis and expression profile reveal the
RT   complexity of the Crassostrea gigas apoptosis system.";
RL   Dev. Comp. Immunol. 35:603-610(2011).
CC   -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR   EMBL; HQ425702; AEB54800.1; -; Genomic_DNA.
DR   AlphaFoldDB; F5A8D6; -.
DR   HOGENOM; CLU_016347_2_0_1; -.
DR   GO; GO:0043067; P:regulation of programmed cell death; IEA:UniProt.
DR   CDD; cd00022; BIR; 2.
DR   CDD; cd16713; RING-HC_BIRC2_3_7; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10044:SF139; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2; 1.
DR   PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR   Pfam; PF00653; BIR; 2.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00238; BIR; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 2.
DR   PROSITE; PS01282; BIR_REPEAT_1; 1.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          534..569
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          213..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          489..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  65702 MW;  6A3F741943BE05BE CRC64;
     MNYEGEKEKA SRKNSTRGIT LLLNEEKNRI KERHRNPIID TNFSNSDAGK VRLETECLRS
     KQNGVRGNSL KESLDTISRY TGSFEEFVQK EISSNRDLEN QAHSLASPLC HSMNMELIRL
     RSFHNFPSSK TISTLRLARK GFYYSMEYDV TICFACGFRK RDWRSDDVIE VIHRNMSPDC
     PLLSAQPTSN IQIGNDQRDG HCINELEQQF NASGNEFPRR SNRQPSSSTS EIASSGHEIK
     REQNTDNIDN KGSGKAPSSH KTSNDLLTKT RIQQDKINAF IRNLDPLGIN FDRPKYPSYS
     VLAVRVSSFA DWPSSLSQTP RDLAVAGFLY AGYGDYTRCF FCGGGLRNWE PGDDPWTEHA
     RWFPKCAFVR QNKGDEFVAL VQIQHQELEA MGPPNENQAG DHATVTEPEY VTSERSSEPH
     VSSLPAFQSV LEMGYPSHVI QQAFNFLKHK KECIDIKAEE VMEVILSGDD IPPSSAAETS
     DNVKDITVKS NEDSKHANEQ QTKSSLMADT KEFEEADTRS LIEENRQLKD LRMCKICMEK
     DASIAMLPCG HLCCCTDCAP AMRKCPICRQ YVKGTVRTWL A
//