ID F5B954_DROSI Unreviewed; 74 AA.
AC F5B954;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=nitric-oxide synthase (NADPH) {ECO:0000256|ARBA:ARBA00012989};
DE EC=1.14.13.39 {ECO:0000256|ARBA:ARBA00012989};
DE Flags: Fragment;
GN Name=Nos {ECO:0000313|EMBL:AEB91044.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AEB91044.1};
RN [1] {ECO:0000313|EMBL:AEB91044.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MD255 {ECO:0000313|EMBL:AEB91044.1};
RX PubMed=21491976; DOI=10.1139/g10-120;
RA Minuk L., Civetta A.;
RT "Drosophila genomes and the development of affordable molecular markers for
RT species genotyping.";
RL Genome 54:341-347(2011).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SIMILARITY: Belongs to the NOS family. {ECO:0000256|ARBA:ARBA00006267}.
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DR EMBL; HQ678133; AEB91044.1; -; Genomic_DNA.
DR AlphaFoldDB; F5B954; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004517; F:nitric-oxide synthase activity; IEA:EnsemblMetazoa.
DR GO; GO:0007399; P:nervous system development; IEA:EnsemblMetazoa.
DR GO; GO:0002027; P:regulation of heart rate; IEA:EnsemblMetazoa.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR43410; NITRIC OXIDE SYNTHASE OXYGENASE; 1.
DR PANTHER; PTHR43410:SF1; NITRIC OXIDE SYNTHASE OXYGENASE; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022643};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; Heme {ECO:0000256|ARBA:ARBA00022617};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 19..68
FT /note="Sulfite reductase [NADPH] flavoprotein alpha-
FT component-like FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00667"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEB91044.1"
FT NON_TER 74
FT /evidence="ECO:0000313|EMBL:AEB91044.1"
SQ SEQUENCE 74 AA; 8177 MW; 7F04A2B2CD8439C5 CRC64;
LSKYHNKKVH CCKAKSQPHN LTRLSEGAKT TMLLEICAPG LEYEPGDHVG IFPANRTELV
DGLLNRLVGV DHPD
//
