ID F5C0R3_HBV Unreviewed; 767 AA.
AC F5C0R3;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AEA48412.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AEA48412.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEA48412.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ANG03F2 {ECO:0000313|EMBL:AEA48412.1};
RA Fallot G.;
RT "Recombination of Hepatitis B virus DNA during antiviral therapies.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; JF439786; AEA48412.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 356..599
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 184..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 767
FT /evidence="ECO:0000313|EMBL:AEA48412.1"
SQ SEQUENCE 767 AA; 86358 MW; 3DE16B8C317CA53A CRC64;
MPLSYQHFRR LLLLDEEAGP LEEELPRLAD EDLNRRVAED LHLQLPNVSI PWTHKVGNFT
GLYSSTIPVF NPDWQTPSFP NIHLHQDIIT KCEQFVGPLT VNEKRRLKLV MPARFFPNST
KYLPLDKGIK PYYPENVVNH YFQTRHYLHT LWKPGILYKR ETSRSASFCG SPYTWEQDLQ
HGAFLDGPSR VGKEPFHQQS SRIPSRSPVG PGIQSKYQQS RLGLQSQKGP LARGQQGRSW
SLWTRVHPST RRPFGVEPSV SGHTNNFASR SASCLHQSSV REAAYSHLST TKRQSSSGHA
VELYSIPPSS TKSQSQGPVS SCWWLQFRDS EPCSDYCLSH LVNLHQDWGP CTEHGEHHIR
IPRTPARVTG GVFLVDKNPH NTAESRLVVD FSQFSRGSAR VSWPKFAVPN LQSLTNLLSS
NLSWLSLDVS AAFYHIPLHP AAMPHLLVGS SGLSRYVARL SSDSRILDHQ YGTLQNLHDS
CSRQLYVSLM LLYKTFGRKL HLYSHPIILG FRKIPMGVGL SPFLMAQFTS AICSVVRRAF
PHCLAFSYVD DIVLGAKSVQ HLESLYTAVT NFLLSLGIHL NPNKTKRWGY SLNFMGYVIG
SWGTLSQEHI TQKIKQCFRK LPVNRPIDWK VCQRITGLLG FAAPFTQCGY PALMPLYACI
QAKQAFTFSP TYKAFLCKQY MNLYPVARQR PGLCQVFADA TPTGWGLAIG HQRMRGTFVA
PLPIHTAELL AACFARSRSG AKLIGTDNSV VLSRKYTSFP WLLGCAA
//