ID F5GYX2_HUMAN Unreviewed; 310 AA.
AC F5GYX2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ankyrin repeat domain 12 {ECO:0000313|Ensembl:ENSP00000441510.2};
DE Flags: Fragment;
GN Name=ANKRD12 {ECO:0000313|Ensembl:ENSP00000441510.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441510.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000441510.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000441510.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP001033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP005263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F5GYX2; -.
DR SMR; F5GYX2; -.
DR EPD; F5GYX2; -.
DR MassIVE; F5GYX2; -.
DR MaxQB; F5GYX2; -.
DR PeptideAtlas; F5GYX2; -.
DR ProteomicsDB; 24869; -.
DR Antibodypedia; 6510; 73 antibodies from 12 providers.
DR Ensembl; ENST00000546007.6; ENSP00000441510.2; ENSG00000101745.17.
DR UCSC; uc060nft.1; human.
DR HGNC; HGNC:29135; ANKRD12.
DR VEuPathDB; HostDB:ENSG00000101745; -.
DR GeneTree; ENSGT00940000154742; -.
DR HOGENOM; CLU_028245_0_0_1; -.
DR ChiTaRS; ANKRD12; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000101745; Expressed in calcaneal tendon and 199 other cell types or tissues.
DR ExpressionAtlas; F5GYX2; baseline and differential.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24149; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR24149:SF16; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Proteomics identification {ECO:0007829|EPD:F5GYX2,
KW ECO:0007829|MaxQB:F5GYX2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REPEAT 159..191
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 192..224
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 225..257
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 310
FT /evidence="ECO:0000313|Ensembl:ENSP00000441510.2"
SQ SEQUENCE 310 AA; 34397 MW; 790160DD3066E7B1 CRC64;
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR
KLPFTISPSR NEERDSDTEK EGPEKKKTKK EAGNKKSTPV SILFGYPLSE RKQMALLMQM
TARDNNSTPN HPSQTTPAQK KTPSSSSRQK DKVNKRNERG ETPLHMAAIR GDVKQVKELI
SLGANVNVKD FAGWTPLHEA CNVGYYDVAK ILIAAGADVN TQGLDDDTPL HDSASSGHRD
IVKLLLRHGG NPFQANKHGE RPVDVAETEE LELLLKREVP LSDDDESYTD SEEAQSVNPS
SVDENIDSET
//
