ID F5HS94_9POAL Unreviewed; 1141 AA.
AC F5HS94;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:BAK23260.1};
GN Name=PutNHA {ECO:0000313|EMBL:BAK23260.1};
OS Puccinellia tenuiflora.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Poodae; Poeae; Poeae Chloroplast Group 2 (Poeae type);
OC PPAM clade; Coleanthinae; Puccinellia.
OX NCBI_TaxID=240906 {ECO:0000313|EMBL:BAK23260.1};
RN [1] {ECO:0000313|EMBL:BAK23260.1}
RP NUCLEOTIDE SEQUENCE.
RA Kobayashi S., Abe N., Xie L., Yoshida K.T., Liu S., Takano T.;
RT "Molecular cloning and characterization of plasma membrane- and vacuolar-
RT type Na+/H+ antiporters of an alkaline-salt-tolerant monocot, Puccinellia
RT tenuiflora.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out);
CC Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00033682};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000256|ARBA:ARBA00033620};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AB628205; BAK23260.1; -; mRNA.
DR AlphaFoldDB; F5HS94; -.
DR SMR; F5HS94; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 720..822
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 986..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1044
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 126289 MW; C5B984CA743521DC CRC64;
MEEAGSSPDD AVLFFGVSLV LGIGSRHLLR GTRVPYTVAL LVLGFALGGL EYGTKHGLGK
LGAGIRIWAA INPDLLLAVF LPALLFESSF SMEVHQIKKC MAQMMLLAIP GVVLSTVLLG
SAVKLTFPYN WNWKTSFLFG GLLSATDPVA VVALLKDLGA SKKLSTIIEG ESLMNDGTAI
VVYQLFYRMV LGKTFDAGSI IKFLTEVSLG AVALGLAFGI ASVLWLGFIF NDTIIEISLT
LAVSYIAFFT AQDAFEVSGV LAVMTLGMFY AAFAKTAFKG DSQESLHHFW EMIAYIANTL
IFILSGVVIA DGVLQDNIHF ERHGASWGFL LLLYAFVLTA RAVVVTVLFP LLRHFGYGMD
VKEATVLVWS GLRGAVALSL SLSVKRASDA DQPYLRSEVG TMFVFFTGGI VFLTLIVNGS
TTQFLLHLLG LGKLSATKLR VLKYTRYEMQ NKAREAFGDL RDDEELGPAD WVTVKKYITC
LNNLEDEQAH PHDAPDKDEN VHTMNLRDTR VRLLNGVQAA YWEMLEEGRI TQSTANILMR
SVDEAMDLVS TQSLCDWKGL RSNVQFPKYY RFLQMSRLPR RVVTYFTVER LELGCYICAA
FLRAHRIARR QLHDFLGDSE IARIVIDEST AAGEEAKKFL EDVRLTFPQV LHALKTRQVT
YAVLTHLSEY IQDLGKTGLL EEKEMVHLDD ALQTDLKKLK RNPPLAKMPR VSELLNTHPL
VGALPAAVRD PLLSGTKETI KVHGTILYSE GSRPTGIWLV STGIVKWTSQ RLSTRHSLDP
ILSHGSTLGL YEALVGKPYI CDIITESVVH CFFIEAEKIE QLRQSDPSIE DFLWQESALV
IARIFLPQIF EKMAMREMRV LISERSTMNI YIKGEDIELG HNYVCILLEG FLKTNQTLIT
PPAVLLPSNT DLNVFGLQSS AMNHIDYCYT APSYQVEARA RAILFDIRSP EAESDMQRSA
SLLSPKLGPP RTQSKEHIGL LRWPQSFHHR SRGPGNPSLA EIGKQPGSFS ARALQVSMYG
SMMDDEMHTA QPRPRPDRVE ANQKHSSSYP KVPSRPLSNT RPLLSVRSEG SNMMKRKSAP
APAPAPAHAP ALAPFPALAA GRHHRAITED GNLSDESTGE EVIVRVDSPS MLAFQPPSQG
N
//
