ID   F5RE81_METUF            Unreviewed;       642 AA.
AC   F5RE81;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE            EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN   ORFNames=METUNv1_02599 {ECO:0000313|EMBL:EGK71212.1};
OS   Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / FAM5).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Sterolibacteriaceae; Methyloversatilis.
OX   NCBI_TaxID=1000565 {ECO:0000313|EMBL:EGK71212.1, ECO:0000313|Proteomes:UP000005019};
RN   [1] {ECO:0000313|EMBL:EGK71212.1, ECO:0000313|Proteomes:UP000005019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1314 / JCM 13912 / FAM5
RC   {ECO:0000313|Proteomes:UP000005019};
RX   PubMed=21725020; DOI=10.1128/JB.05331-11;
RA   Kittichotirat W., Good N.M., Hall R., Bringel F., Lajus A., Medigue C.,
RA   Smalley N.E., Beck D., Bumgarner R., Vuilleumier S., Kalyuzhnaya M.G.;
RT   "Genome sequence of Methyloversatilis universalis FAM5T, a methylotrophic
RT   representative of the order Rhodocyclales.";
RL   J. Bacteriol. 193:4541-4542(2011).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGK71212.1}.
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DR   EMBL; AFHG01000052; EGK71212.1; -; Genomic_DNA.
DR   RefSeq; WP_008062324.1; NZ_AFHG01000052.1.
DR   AlphaFoldDB; F5RE81; -.
DR   STRING; 1000565.METUNv1_02599; -.
DR   eggNOG; COG1639; Bacteria.
DR   eggNOG; COG3706; Bacteria.
DR   OrthoDB; 9813903at2; -.
DR   Proteomes; UP000005019; Unassembled WGS sequence.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd17574; REC_OmpR; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR013976; HDOD.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR   PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08668; HDOD; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS51833; HDOD; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005019}.
FT   DOMAIN          19..214
FT                   /note="HDOD"
FT                   /evidence="ECO:0000259|PROSITE:PS51833"
FT   DOMAIN          330..446
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          510..642
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   COILED          441..468
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   MOD_RES         379
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   642 AA;  69477 MW;  455FDBB71B57E9DC CRC64;
     MNDLIDTRRF EEIKAAGELP SPKGIALSIA RMSQRGDASL AELARLVQGD PALVGRLVRA
     ANGSLASGAR PVVALRDALA VLGMAAVRNL ALGFSLISSS GEGLCRSFPY ARFWTGSVIR
     AIAMQKILMR LRTAGVEESF SVGLLAGIGA LGLASVFPAQ YSRVLDEARG DPVALLDLER
     QAFAMSHVEL SAAMLADWGM PRFFVAAVLR HEGALTLPAE DGSREYGLTL ALGLARAIET
     ACMADDAGRS EAVDAAKALA ARMEWVPEQV SALCEDVAAD WKDWSAMLPV DAYALPNLSM
     SAEPETLAPP QPPAAFPSAA NDAPAGDGLR VLVVDDDAAT RLTLQTLLVR GGYRVATAED
     GVRGMECALE FQPHIMVVDW VMPQMNGLEL ARTLRQTRMG RSIYIIVLTS HEEDARLVEA
     FESGVDDYMV KPLRPRVLEA RLRAAQRLVR MQRELETERE EIRRYAAELG VSNRRLQEVS
     MTDALTGFPN RRYAMERIAQ EWAIAQRSNR SLSCMLIDVD HFRQINETYG RDVADQVLEQ
     TARAIRACMR TQDVVCRTGG DEFLIICPDT DLQQALACAQ RVGAGVAAVP VQAGRLRLKS
     SISVGVAERL PAMPDADALL TLADQALLAA KKAGRNCVRT AG
//