ID F5X4U7_STRPX Unreviewed; 330 AA.
AC F5X4U7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=PTS system mannose-specific EIIAB component {ECO:0000256|ARBA:ARBA00021685};
DE EC=2.7.1.191 {ECO:0000256|ARBA:ARBA00011929};
DE AltName: Full=EIIAB-Man {ECO:0000256|ARBA:ARBA00032197};
DE AltName: Full=EIII-Man {ECO:0000256|ARBA:ARBA00030229};
GN Name=manL {ECO:0000313|EMBL:BAK29437.1};
GN OrderedLocusNames=SGPB_0303 {ECO:0000313|EMBL:BAK29437.1};
OS Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=981540 {ECO:0000313|EMBL:BAK29437.1, ECO:0000313|Proteomes:UP000007946};
RN [1] {ECO:0000313|EMBL:BAK29437.1, ECO:0000313|Proteomes:UP000007946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43144 / JCM 5346 / CDC 1723-81
RC {ECO:0000313|Proteomes:UP000007946};
RX PubMed=21633709; DOI=10.1371/journal.pone.0020519;
RA Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M.,
RA Chang C.-H., Hsu M.-T.;
RT "Sequencing and comparative genome analysis of two pathogenic Streptococcus
RT gallolyticus subspecies: genome plasticity, adaptation and virulence.";
RL PLoS ONE 6:E20519-E20519(2011).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II ManXYZ PTS system is involved in mannose transport.
CC {ECO:0000256|ARBA:ARBA00023757}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC mannose 6-phosphate(in) + L-histidyl-[protein]; Xref=Rhea:RHEA:49232,
CC Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:4208,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:58735, ChEBI:CHEBI:64837;
CC EC=2.7.1.191; Evidence={ECO:0000256|ARBA:ARBA00000514};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AP012054; BAK29437.1; -; Genomic_DNA.
DR RefSeq; WP_013851477.1; NC_015600.1.
DR AlphaFoldDB; F5X4U7; -.
DR STRING; 981540.SGPB_0303; -.
DR GeneID; 64018130; -.
DR KEGG; stb:SGPB_0303; -.
DR HOGENOM; CLU_074797_0_0_9; -.
DR Proteomes; UP000007946; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00006; PTS_IIA_man; 1.
DR CDD; cd00001; PTS_IIB_man; 1.
DR Gene3D; 3.40.50.510; Phosphotransferase system, mannose-type IIA component; 1.
DR Gene3D; 3.40.35.10; Phosphotransferase system, sorbose subfamily IIB component; 1.
DR InterPro; IPR004701; PTS_EIIA_man-typ.
DR InterPro; IPR036662; PTS_EIIA_man-typ_sf.
DR InterPro; IPR033887; PTS_IIA_man.
DR InterPro; IPR004720; PTS_IIB_sorbose-sp.
DR InterPro; IPR036667; PTS_IIB_sorbose-sp_sf.
DR PANTHER; PTHR33799:SF1; PHOSPHOTRANSFERASE ENZYME IIA COMPONENT YADI-RELATED; 1.
DR PANTHER; PTHR33799; PTS PERMEASE-RELATED-RELATED; 1.
DR Pfam; PF03610; EIIA-man; 1.
DR Pfam; PF03830; PTSIIB_sorb; 1.
DR SUPFAM; SSF52728; PTS IIb component; 1.
DR SUPFAM; SSF53062; PTS system fructose IIA component-like; 1.
DR PROSITE; PS51096; PTS_EIIA_TYPE_4; 1.
DR PROSITE; PS51101; PTS_EIIB_TYPE_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000007946};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAK29437.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..130
FT /note="PTS EIIA type-4"
FT /evidence="ECO:0000259|PROSITE:PS51096"
FT DOMAIN 166..330
FT /note="PTS EIIB type-4"
FT /evidence="ECO:0000259|PROSITE:PS51101"
SQ SEQUENCE 330 AA; 35509 MW; 0928D3A361518F5E CRC64;
MGIGIIIASH GKFAEGIHQS GSMIFGEQEK VQVVTFMPSE GPDDLYAHFN DAIAQFDADD
EILVLADLWS GSPFNQASRV MGENPDRKMA IITGLNLPML IQAYTERMMD ANAGVEQVVA
NIIKESKDGV KALPEELNPA EKAAAAPVAQ AAPQGAIPEG TIIGDGKLKI NLARIDTRLL
HGQVATNWTP ASKADRIIVA SDTVSKDELR KGLIKQAAPN GVKANVVPIK KLIEAAKDPR
FGNTHALILF ETPQEALEAI EGGVPIKELN VGSMAHSTGK TMVNNVLSMD KDDVATFEKL
RDLGVTFDVR KVPNDSKKDL FDLIKKANVQ
//
