ID F5YSF3_MYCSD Unreviewed; 550 AA.
AC F5YSF3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=ercc3 {ECO:0000313|EMBL:AEF34789.1};
GN OrderedLocusNames=JDM601_0789 {ECO:0000313|EMBL:AEF34789.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF34789.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF34789.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF34789.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP002329; AEF34789.1; -; Genomic_DNA.
DR RefSeq; WP_013827731.1; NC_015576.1.
DR AlphaFoldDB; F5YSF3; -.
DR STRING; 875328.JDM601_0789; -.
DR KEGG; mjd:JDM601_0789; -.
DR eggNOG; COG1061; Bacteria.
DR HOGENOM; CLU_008213_4_0_11; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AEF34789.1};
KW Helicase {ECO:0000313|EMBL:AEF34789.1};
KW Hydrolase {ECO:0000313|EMBL:AEF34789.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AEF34789.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224}.
FT DOMAIN 191..345
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 399..546
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 550 AA; 60692 MW; 961FBC0DED0529D5 CRC64;
MSTDGPLIVQ SDKTVLLEVD HEQAGAARAA IAPFAELERA PEHVHTYRIT PLALWNARAA
GHDAEQVVDA LVSHSRYAVP QPLLVDIVDT MARYGRLQLV KSPVHGLTLV SLDRAVLEEV
LRNKKIAPML GARIDDDTVV VHPSERGRVK QMLLKIGWPA EDLAGYVDGE AHPIALCQDG
WQLRDYQEMA ADSFWSGGSG VVVLPCGAGK TLVGAAAMAK AGATTLILVT NTVAGRQWKR
ELIARTSLTE EEIGEYSGER KEIRPVTIAT YQVITRRTKG EYRHLELFDS RDWGLIIYDE
VHLLPAPVFR MTADLQSRRR LGLTATLIRE DGREGDVFSL IGPKRYDAPW KDIEAQGWIA
PAECIEVRVT MTESERMTYA IAEPEERYKL CSTVHSKIAV VRSILKQHPG EQTLVIGAYL
DQLEELGEQL DAPVIQGSTR TAEREKLFDA FRKGEVSTLV VSKVANFSID LPEASVAVQV
SGTFGSRQEE AQRLGRLLRP KADGGGAVFY SVVARDSLDA EYAAHRQRFL AEQGYGYIIR
DADDLLGPAI
//
