ID F5Z2T8_MYCSD Unreviewed; 229 AA.
AC F5Z2T8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN OrderedLocusNames=JDM601_1875 {ECO:0000313|EMBL:AEF35875.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF35875.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF35875.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF35875.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; CP002329; AEF35875.1; -; Genomic_DNA.
DR RefSeq; WP_013828811.1; NC_015576.1.
DR AlphaFoldDB; F5Z2T8; -.
DR STRING; 875328.JDM601_1875; -.
DR KEGG; mjd:JDM601_1875; -.
DR eggNOG; COG0693; Bacteria.
DR HOGENOM; CLU_070319_1_0_11; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000009224; Chromosome.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009224};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 27..224
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 229 AA; 24672 MW; CCED25719448A588 CRC64;
MTKHILNVVS NVAHYDDPAE PTGLWLSELT HAYQIFADAG YQQTIASPKG GPSPLEPRSL
KFPNFDKSAK AWHADAAKMA LLAGTASPDE IDPADFDAIY FTGGHAVMFD FPDSQGLQRI
TREIFERGGI VSSVCHGYCG LLNTRLSDGS LLVSGRRLTG FAWVEEVLAR VNKLVPYNAE
AEMKKRGARY QKGLLPFASH VVADGRLVTG QNPGSAKATA KKIVSVLGG
//
