ID F6DA79_THICA Unreviewed; 749 AA.
AC F6DA79;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Lysine decarboxylase {ECO:0000313|EMBL:AEG32210.1};
DE EC=4.1.1.18 {ECO:0000313|EMBL:AEG32210.1};
GN OrderedLocusNames=Thicy_1450 {ECO:0000313|EMBL:AEG32210.1};
OS Thiomicrospira cyclica (strain DSM 14477 / JCM 11371 / ALM1)
OS (Thioalkalimicrobium cyclicum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Thiomicrospira.
OX NCBI_TaxID=717773 {ECO:0000313|EMBL:AEG32210.1, ECO:0000313|Proteomes:UP000009232};
RN [1] {ECO:0000313|EMBL:AEG32210.1, ECO:0000313|Proteomes:UP000009232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14477 / JCM 11371 / ALM1
RC {ECO:0000313|Proteomes:UP000009232};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Davenport K., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Kappler U., Woyke T.;
RT "Complete sequence of Thioalkalimicrobium cyclicum ALM1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC {ECO:0000256|ARBA:ARBA00010671}.
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DR EMBL; CP002776; AEG32210.1; -; Genomic_DNA.
DR RefSeq; WP_013835985.1; NC_015581.1.
DR AlphaFoldDB; F6DA79; -.
DR STRING; 717773.Thicy_1450; -.
DR KEGG; tcy:Thicy_1450; -.
DR eggNOG; COG1982; Bacteria.
DR HOGENOM; CLU_014292_3_0_6; -.
DR OrthoDB; 9761189at2; -.
DR Proteomes; UP000009232; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008923; F:lysine decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.90.100.10; Orn/Lys/Arg decarboxylase, C-terminal domain; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR005308; OKR_de-COase_N.
DR InterPro; IPR011193; Orn/lys/arg_de-COase.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR45229:SF3; BIODEGRADATIVE ARGININE DECARBOXYLASE; 1.
DR PANTHER; PTHR45229; CONSTITUTIVE ORNITHINE DECARBOXYLASE; 1.
DR Pfam; PF01276; OKR_DC_1; 1.
DR Pfam; PF03711; OKR_DC_1_C; 1.
DR Pfam; PF03709; OKR_DC_1_N; 1.
DR PIRSF; PIRSF009393; Orn_decarb; 1.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AEG32210.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR009393-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009232}.
FT DOMAIN 20..143
FT /note="Orn/Lys/Arg decarboxylase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03709"
FT DOMAIN 149..580
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 607..731
FT /note="Orn/Lys/Arg decarboxylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03711"
FT MOD_RES 394
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR009393-1"
SQ SEQUENCE 749 AA; 84196 MW; 0AD8B234A62E06CA CRC64;
MKFRFPVVII DEDFRSENAS GTGVRALADA IESAGMETLG VTSFNDTAMI AQQQNRASCF
ILSIDDDEFA DEELKDSAIA KLRLFVEEIR NRNSDIPIFL YGETRTSRHI PNDVLKELHG
FIHMFEDTPE FVARHIMREA RVYLDGLAPP FFRALTGYAA DGSYSWHCPG HSGGVAFLKS
PVGQMFHQFF GENMLRADVC NAVDELGQLL DHTGAVADSE HNAARIFGAD HLFFVTNGTS
TSNKIVWHAN VADNDVVVVD RNCHKSVLHS IIMTGAVPVF LMPTRNHYGI IGPIPESEFH
PDTIKQKIAA NPLVKNPNAK PQMLTITQST YDGILYNVDK IKKTLGESVE NLHFDEAWLP
HATFHEFYKG MHAIGRDTNR SEGPMVYACQ STHKLLAGLS QASQILVQES PKRMLDRGRF
NEAYLMHVST SPQYAIIASC DVAAAMMEPP GGTALVEESI AEAIDFRRAM RKVDEEYGDS
WWFKVWGPDE LAEEGIGERD DWVLRTDDPW HGFGNLASNF NMLDPIKATI ITPGLAVNGD
FSESGIPAAI VTRYLAEHGV IIEKTGLYSF FIMFTIGITK GRWNTMVTAL QQFKDDYDRN
MPLWRVLPGF IKKYPRYERI GLRDLCNAIH NMYRESDVAR LTTEMYTSHM EPAMKPADAY
AMMVHNKIER VEVDDLEGRI TAVLLTPYPP GIPLLIPGER VNKTILNYLK FAQTFNEKFP
GFETDVHGLE KIEKDGKTVY AMDCVKRDV
//
