ID F6EUL0_SPHCR Unreviewed; 547 AA.
AC F6EUL0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:AEG48728.1};
DE EC=1.1.99.1 {ECO:0000313|EMBL:AEG48728.1};
GN ORFNames=Sphch_1037 {ECO:0000313|EMBL:AEG48728.1};
OS Sphingobium chlorophenolicum L-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=690566 {ECO:0000313|EMBL:AEG48728.1, ECO:0000313|Proteomes:UP000007150};
RN [1] {ECO:0000313|EMBL:AEG48728.1, ECO:0000313|Proteomes:UP000007150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L-1 {ECO:0000313|EMBL:AEG48728.1,
RC ECO:0000313|Proteomes:UP000007150};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Daligault H., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Pagani I., Turner P., Copley S., Woyke T.;
RT "Complete sequence of chromosome 1 of Sphingobium chlorophenolicum L-1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR EMBL; CP002798; AEG48728.1; -; Genomic_DNA.
DR RefSeq; WP_013846991.1; NC_015593.1.
DR AlphaFoldDB; F6EUL0; -.
DR STRING; 690566.Sphch_1037; -.
DR KEGG; sch:Sphch_1037; -.
DR HOGENOM; CLU_002865_7_2_5; -.
DR Proteomes; UP000007150; Chromosome 1.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Oxidoreductase {ECO:0000313|EMBL:AEG48728.1}.
FT DOMAIN 89..112
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 261..275
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 91
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 226
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 547 AA; 59494 MW; BEC3FB779870FF6E CRC64;
MDMAHNDVGN SYDYVVIGAG SSGCVVANRL SEDGTHSVLL IEAGGPDNLF WMRAPLGTGQ
MLRRTDVIWP YETEGVPALN GRKLRWPRGK VVGGSSSVNG TIFIRGLREE YDRWREMGNI
GWGYDDVLPF FKKFENFKDG DPRYRGKGGP ISVERLRLNL PVTSAFLDAC AQAGIPGNAD
YNGASIEGAS PLQFNTRYGR RQSAAVGYLS SAAKRKNLHV LANTRVKKID VVDGAASGVV
LQNAAGERTV RANREIIISA GAIGSPQLLE LSGIGNAFIL KNAGLSVVHH LPGVGENLID
HLQTRISLKA QNTAGLNELV RNYLFRMKVG AEWLFLGRGL MSTPLASAHA IVRSRPDAPM
PDLKLQLHHF SGQDRMAYSK DLGIDPHPGL TIGIVQLSPR SRGHLHISSP DANVAPLIYP
NQFEDEEDVR VLTAGIRMAR TIAAQDALSK FVVTELRPGE AASSNDEIKE YIRQSGQTSY
HPIGTCKMGR DDWAVVDDQL RVRGIDRLRV VDASIMPTMP SSNTNAAALM IGEKGAELIR
QAAAQKF
//
