ID F6FX33_ISOV2 Unreviewed; 466 AA.
AC F6FX33;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Transcriptional regulator, GntR family with aminotransferase domain {ECO:0000313|EMBL:AEG44633.1};
GN OrderedLocusNames=Isova_1890 {ECO:0000313|EMBL:AEG44633.1};
OS Isoptericola variabilis (strain 225).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Promicromonosporaceae; Isoptericola.
OX NCBI_TaxID=743718 {ECO:0000313|Proteomes:UP000009236};
RN [1] {ECO:0000313|EMBL:AEG44633.1, ECO:0000313|Proteomes:UP000009236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=225 {ECO:0000313|Proteomes:UP000009236};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M., Thelen M.,
RA Hugenholtz P., Gladden J., Woyke T.;
RT "Complete sequence of Isoptericola variabilis 225.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP002810; AEG44633.1; -; Genomic_DNA.
DR RefSeq; WP_013839025.1; NC_015588.1.
DR AlphaFoldDB; F6FX33; -.
DR STRING; 743718.Isova_1890; -.
DR KEGG; iva:Isova_1890; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_1_11; -.
DR Proteomes; UP000009236; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AEG44633.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000009236};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AEG44633.1}.
FT DOMAIN 12..80
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 466 AA; 49927 MW; 5E8365822A1B811D CRC64;
MTELFVDPAD PRPLTQQLYE QLRSAVVEGR LAPGARLTPT RRAAAELGVS RSTVAEAYAR
LVAEGYVEGR RGGGSVVAAV ATTPPQTARD ATALVPAART RGLRPYEPEP APGVAWDLRP
GVVDDDLFRA SAWRRCLARA AAETTGHYTD PAGTPELRAA LAHWVTRSRG VVAVPDQVVV
TAGAGHATDL VARTLLDPPA VVAVEEPGYP PVVELLRHHG HHVVGVPVDD QGIVVDAIPR
DVRLVYVTPS HQYPLGMVMS RPRRAELLAW ASRARAAIVE DDYDSEFRHT ARPLEPLQRL
DRDGRVIYVG TFSKSLSPGL RLGFAVVPRG LASAVASVRQ TVDWSPPLAS QAALTAFVTE
GHLDRHLRRC RTVYRERQHL VRTQLERLLP PGCAVLPAHA GLHLAVTTPH HDAVQRLRSS
SPSLRAGSLA RTYLFSDPVP GLLVGFGGVP TAAVPTAVGA LTAALA
//
