ID F6GBC1_RALS8 Unreviewed; 4196 AA.
AC F6GBC1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Rhie polyketide synthase, rhizoxin biosynthesis {ECO:0000313|EMBL:AEG71851.1};
GN Name=rhiE {ECO:0000313|EMBL:AEG71851.1};
GN OrderedLocusNames=RSPO_m01215 {ECO:0000313|EMBL:AEG71851.1};
OS Ralstonia solanacearum (strain Po82).
OG Plasmid {ECO:0000313|Proteomes:UP000007953}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=1031711 {ECO:0000313|EMBL:AEG71851.1, ECO:0000313|Proteomes:UP000007953};
RN [1] {ECO:0000313|EMBL:AEG71851.1, ECO:0000313|Proteomes:UP000007953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Po82 {ECO:0000313|Proteomes:UP000007953};
RX PubMed=21685279; DOI=10.1128/JB.05384-11;
RA Xu J., Zheng H.J., Liu L., Pan Z.C., Prior P., Tang B., Xu J.S., Zhang H.,
RA Tian Q., Zhang L.Q., Feng J.;
RT "Complete genome sequence of the plant pathogen Ralstonia solanacearum
RT strain Po82.";
RL J. Bacteriol. 193:4261-4262(2011).
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DR EMBL; CP002820; AEG71851.1; -; Genomic_DNA.
DR KEGG; rsn:RSPO_m01215; -.
DR PATRIC; fig|1031711.3.peg.4414; -.
DR HOGENOM; CLU_000022_58_3_4; -.
DR Proteomes; UP000007953; Plasmid megaplasmid.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:AEG71851.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 327..404
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 448..870
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1539..1616
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1651..2068
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3027..3100
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3167..3603
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4112..4193
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1510..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4086..4116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4196 AA; 453121 MW; 796535A481F4BD42 CRC64;
MESPIRVLYR KIQNEEISVE AAAREFETIR ASHRREHAER AIQAPPATEN PIAAAVYQHD
EPYLRDHQFN HRRILLGLTY ASLALESGLG QLADGEALQL KRLTFAAPVA LAEGERVEVA
IRAAHQEGPA FEAVCRHAAS APWRPVASGE LSAVAARQLQ VDPAGLRTGM TAVEPLASIY
RISGQIHIGD SFRTLESLYW RQDGGEALSR VALTALDAAD ARRYSLHPLL INSAFLTVIP
LLAKAALDGD FIPFGIQSLI LHRRQVTPTG WIHAKLVKNS GELVLFDATL YGDDGVLVAE
FNGCSLKRVR GSQLEGGESA GEGEPLSGSE GIESYLLAQL HALGADHIGK KQRRRNLMDL
GLESMQLVRL AGRIASAAAI ELEPTVFFEY PSVAELAAFL WQAHRAAFAP LLAQRSASTN
AAPAAASPVV PGLAASRPDS AFASAGGDRD IAIIGMQGRF GEAGDLDQFW RNIWQGRELI
KEVPADHWDV APWFDADPEA HDRTYSKWGS FIDGVDRFDA DFFNMSRREA QWMDPQVRLL
LQSAYASAEH AGVIKRLRGS RTGVFIGSCF NEYLDKITEL GLPMDPYIAT GSGTIAANRI
SFWFDFKGPS LMFNTACSSS LVALHAACVA LRNGECEMAF VGGSNLLLSS WHYRYFSAIR
ALSPTGRCHT FDARADGYVP GECVATLLLK PLSKALADGD PIHGVIKGSA ALHGGYTPSL
TAPSVAGEEN VIVHAWQDAG IDPRSLSYIE AHGTGTRLGD PIEVNALKRA FARYTGDRGF
CHIGSVKANL GHAEGAAGIA GVLKVLQQMK HGKLPALGHF EQQNPHISLE DSPLVIDTEG
IDWPDQGAPR RAGVSSFGFS GTNAHVVLEA YRERRTFATH RGERVLVPLS ARNAQGLRAQ
AVRLLEHLAQ HAPDLAALAY TLQTGREAMA TRALFMVDSP AQLQQQLQAW IGSEPGTDFG
AASMTAEAAL AAGDTGQLAA LWLAGAEEGD AFDWMRLYGE GPHPARIDLP TYAFGGERYW
LDAPAPAVGH SATAVAETAV AAYSEQWQEV DEPAPGPRME RLICLLGEPQ LRQALVREVG
ELSPQTELIF IAADRSNGRD ADGHYRVAAE DPLQLQEGLQ PLLSAHGSSR VLYLWGMDDR
RWIADSRPIV ALLKAMATTA APVDRVLLAG RANDALERCH LESWIGIERS VGAVMPHCPV
EVAIDLPAPI GDDRRWVRRL WRQLGSGTAS GSRLYRDGRV FRPMLVPASL DAAAEPLALE
RMHTVLITGG LGELGLLLAA ELSSRAKKRT GDVLNLILNG RSPLSAAKRA RLDSLHHGTC
RIFHLQADCA DRPAMAAALA EVLPQSGPID AVIHAAGLQA RSSLFDSAPE AFEAVLNAKV
KTTLALDALL ADRPLALICH FSSSSAMLGD MGACSYAMAN RFQQAYARHM QAGRARRIVS
IHWPLWREGG MAVGDRESTA FYLKSSGLRM LDSAEGLTLL QRIVASEADQ VLVLAGESAR
LQQLVDGIND PAAKPTAKPA TANLAPHRPR SRPELKGLSL EQALLWDLRD LASRPLKAER
HTLGDDTNLA DFGFDSISLA EYARLLSHHY GLKLTPELFF SHATLAKIAA HLLAQHRPAV
EVCYRSEGTR AAELSPMPTV AAAASGPAPN AGAIAIIGIS GRFPGARNPD ELWRLQVEGR
DAVGEIPADR YDWRDYYGDH REDPGKTRCI WMGSVPGVGE FDPLFFEISP REAKTLDPRQ
RLLLQESWNA LEDAGIGARH LQAQRVGMFV GVEEGDFQRL AGDESLTSGH NGILASRLAY
FLNLTGPAMA INTACSSALV ALHQAASSLR NDECEMAIAA GVNLIFSPDA FIGMTQAGML
SPDGKCYTFD RRANGMVPGE AVCCVVLKPL ARAEADGDRI YGVLRGSGIN YDGKTNGITA
PSGAAQQCLL EAVYRRAGID IDAVEYIVTH GTGTQLGDPV EINALNDAFR GSRPGHCALT
STKTNVGHTF AASGLVSVIS LLQAFRHDTI PASLHCEQEN DYIHWQASPF YVNKANKAWP
RAGRDSERLG AVSAFGMSGT NAHVVLESYI RESDAAPFRR PCYLLVLSAK TAEALTARVE
QLGAALEQGG YRDDQLPSIS YTLLEGRHHF RHRLALVAAD LEEARYSLQQ YLAGEKRPNL
FAGEVDRAFS AQKTIVRYLD QLLDDSRNAG DGEIRDLLSG LADCYRQGYD IDGRRLFAAV
RHGACEAPPR LSLPGYPFAR EHYWPDIRRR RQQPAPLAAQ GMAHLHPLVH CNVSTLARQR
FVSRFSGRET FLADHRIGDR LVFPATAYLE LAREAIVRAS ELPPRQVALR NVVWLRPLAF
AAGGGDGEVA LYCELAVNGH DSLSFRIYSL DNGTEQLHAQ GDAQLTASAA SPPQPVDLSA
LRARCNVSER SHDALYRDFE SLGAHYGATF RGAAHLSIGP DLVVGQLSGQ ALDPGLDGVL
LPPGVLDSAL HIAAALGTGA GGQGPAEPAL PFALESLRLY GSVAQALSAG PLTVIAAYSE
ARGAGTVGKV DVRICDGGGE CLVLLDGFSA RKTASERQSA QVAEVTPLED ETAFGSLIRT
PFWSPLDHPG ESIPAAAKPQ LLLLGLPEAV VEGVRRQYGD QVTVLPGAPG ECGAAAYRAA
ALSLFEWLQR RVGSHEGGYL QLFVGQGSDD LRLTALDAML KTAMIENGAW RARLLVLDPA
MGDQAMIRVI GEQNRYHGNA LMRVFANGSL YGRQWRTLAP ESMPQNEATP FRDGGVYAIT
GGAGGLGLIF AEQIVGSCRN PVLYLVGRSA VTQPLQQAID RLQARGAQVH YQSLDVSDAT
AVSRWIDRID AEQGALHGVV HSAGVIRDGL ILHKSAGEFE QVLAAKVAGI EALDEAIGER
PLDFLVCCSS QAAMGNLGQV DYAAANAYMD AFMHYRQDLA ADGKRKGRSL SINWPLWRDG
GMKLAPVIEQ QMRQRFGIAP MPTADGIGSL RQLLTGSVSA QGWVVYGELS RLADIGLPAD
VQPRRPAEPA PGRTAGAADI GDLELKKRIE AFVTGIVADV IQIDAAKIHP AEKFEVYGFD
SIMAVGVTHA LEKHLGSLPK TLLFEHVNVA GLTDHFAVQY RDRFAAMFSG AVAQPATAAG
PAAAEPAPAQ PLPLHRFAAA NRGADGSAAQ EGAPTASVER VEDSELEHYV AVIGLGGYYP
GASDMDGLWR NLANGIDCMS DFPAQRWDHD KLYYKNRKVL GKTTCINGAF IEDVDKFDYS
YFKMPKVYAD HMSPEVRLFL QVAVQTFEDA GYSRETMLSR YGGDVGVLVG TMTNDYPYYG
FESNLFRGAM ASGSGMATIP MTVSYFYGLT GPSLFIDTMC SSSLTCIHTA CQMLKHDETK
MVLAGGLNLM YHPYTTVETS QGNFTSITSA SVNSYGVGAD GTVIGEGVGA VLLKRLDRAI
ADRDQIYGVI KGSAMTNAGE RNGFNVPNPD LQTLAIRQAM DQANVHPSSI SYVEGHGSGT
KLGDPIEVLG LNNAFRWATG DKQFCYLGSI KSNIGHLLAA SGVAGLTKIL LQIKHGQIVP
SIHSGQLNPD IDFADTPFVV PQQLVEWRRP QRTVNGRMQV FPRRAGLTSI AAGGMNAHMI
VEEYPAPADS GGRIPDDQLV FVFSVHKLSV LAENLTGFRD WLASSEAPLS RIAHTLQVGR
NNLRNRLAIR CRSRQALLDA LGACIEGRYR AGADSKIFYR FQENDTAQPP DIDPDDPLIS
PLTRWLDGDK QVDWASLYAE LPVRISLPVY RFEKPRCWYT EPAYESSILN PLMFSNKLHP
LVAQSNATLE PEAMFRTDFI EAELLDYVYG TAGGRRLSAF NFADVALAMP ALVSRLGGRA
LSVSWAFEHD IADWATVAAL EYRVFEIDSE QLELEFDCRR NDGQRVNLGF AVINPLADDA
PPLPQPLLDN AGALFNRQPS HACKRVSAEA VGQRLAQAGH DFAPYLDSVG ELVIGQAGLL
LEGSPPAHRH NHHADNLQLP PDVATTIDKA LYLLLDALGL PQGRAVVRTI ERLCCYAKPA
GRFSVVLSEI VPADGALSLS LLVLDEQAQI CVKADRVSLH LGQQELASLR RDHDLLAGAV
NATAGVRPSV EPAGDPGAAG RQAQDTEPTA GDGESGRGTR VLAFIQQALR DKLGFAAQEI
GESAQLQDLG LDSIMVVQLT DSLNKHFDTK LMPDLFYEKQ RLGELAARLE AGLPQA
//
