ID F6I3U8_VITVI Unreviewed; 1019 AA.
AC F6I3U8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN OrderedLocusNames=VIT_18s0041g01340 {ECO:0000313|EMBL:CCB61671.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CCB61671.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; FN596744; CCB61671.1; -; Genomic_DNA.
DR AlphaFoldDB; F6I3U8; -.
DR PaxDb; 29760-VIT_18s0041g01340-t01; -.
DR eggNOG; ENOG502R41B; Eukaryota.
DR HOGENOM; CLU_001561_0_0_1; -.
DR InParanoid; F6I3U8; -.
DR Proteomes; UP000009183; Chromosome 18.
DR ExpressionAtlas; F6I3U8; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF585; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183}.
FT DOMAIN 13..179
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 966..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 115826 MW; 69553CB12B42EFEC CRC64;
MAFPSSSSSS SQGSYDVFLS FRGEDTRNNF TAHLYQELRT KGINTFIDDD KLERGRLISP
ALVTAIENSM FSIIVLSENY ASSKWCLEEL AKILECMKTR GQRVLPIFYN VDPSDVKKQR
GKFGAALAEH EKNLTENMER VQIWKDALTQ VANLSGWESR NKNELLLIKE IVKHVFNKLI
NICSGDTEKL VGIDARIQEI KMRLRLESDD VGMIGIWGMG GIGKTTLARA LYNEISRQFE
AHSFLEDVGK VLVNKGLIKL QQIFLYDLLE EKDLNTKGFT FIKARLHSKK ALVVLDNVND
PKILECLVGN WDWFGRGSRI IITARDKHLL IAHGVLCYQV PTFNYDEAYG FIKRHSLKHE
LLIGDFLELS KEMIDYAKGL PLALKVLCSS LFGMSKKERR NQLDKLKSTL HKKIEEVLRI
SYDGLDDKEK NIFLDIACFF KGEDKDYVIE ILDGCGFFSS CGIRTLVNKS LISIYGNKLE
MHDLIQEMGI EIVRQQFVQE LGKRSRLWFH EDIIDVLEKL KCMDLSHSKY LIETPNLSRV
TNLERLVLED CVSLCKVHPS LRDLKNLNFL SFKNCKMLKS LPSGPYDLKS LATLILSGCS
KFEQFPENFG YLEMLKKLYA DGTALRELPS SLSSLRNLEI LSFVGCKGPP SASWLFPRRS
SNSTGFILHN LSGLCSLRKL DLSDCNLSDE TNLSCLVYLS SLKDLYLCEN NFVTLPNLSR
LSRLERFRLA NCTRLQELPD LPSSIVQVDA RNCTSLKNVS LRNVQSFLLK NRVIWDLNFV
LALEILTPGS RLPDWIRYQS SGKEVIAELS PNWFNSNFLG FGFANVVPKF SNLGLSRFVY
CYLSLSRSSD FTHGFRVVPY PHFLCLNRQM LTLDHVYLLY VPLSSFSDWC PWGHIINWHQ
VTHIKASFQP RSDQFGEVKR YGIGLAYSNE DVNHNNPPMI QFGSISSASS PPPNKSTVVL
TEIHDEEPSG SVDGSELDNS GYYTADEGEP AETACSKDPS ESEMQPQKRL KCSHFQDIP
//
