ID   F6KJ69_9STRA            Unreviewed;       167 AA.
AC   F6KJ69;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE            EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
DE   Flags: Fragment;
GN   Name=Ura3 {ECO:0000313|EMBL:AEF15650.1};
OS   Phytophthora tropicalis.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=137729 {ECO:0000313|EMBL:AEF15650.1};
RN   [1] {ECO:0000313|EMBL:AEF15650.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21486143; DOI=10.1094/PHYTO-11-10-0325;
RA   Quesada-Ocampo L.M., Granke L.L., Mercier M.R., Olsen J., Hausbeck M.K.;
RT   "Investigating the genetic structure of Phytophthora capsici populations.";
RL   Phytopathology 101:1061-1073(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00001419};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008847}.
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DR   EMBL; HQ389039; AEF15650.1; -; Genomic_DNA.
DR   AlphaFoldDB; F6KJ69; -.
DR   UniPathway; UPA00070; UER00120.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011995; OMPdecase_type-2.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT   DOMAIN          3..129
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|Pfam:PF00215"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEF15650.1"
FT   NON_TER         167
FT                   /evidence="ECO:0000313|EMBL:AEF15650.1"
SQ   SEQUENCE   167 AA;  17397 MW;  2E808D86E40530C1 CRC64;
     GVDSIDPFVR GHPERGCFVL CKTSNPSAND FQTLSVGSRA LFEEVAAKCE QWNSEDNVGL
     VVGATDIEAL RRVRAVTPNL WILAPGIGAQ GGNLEEAVTA GLSADGLGLL VPVSRGISKA
     ANPKEAAESL RDAINAVRKT KVTAASTVVT SSSANEFIKF ALSFGVL
//