ID F6LI76_XENLA Unreviewed; 855 AA.
AC F6LI76;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE SubName: Full=Prominin-1 transcript variant 7 {ECO:0000313|EMBL:AEG21035.1};
GN Name=Prom-1 {ECO:0000313|EMBL:AEG21035.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AEG21035.1};
RN [1] {ECO:0000313|EMBL:AEG21035.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21655362;
RA Han Z., Papermaster D.S.;
RT "Identification of three prominin homologs and characterization of their
RT messenger RNA expression in Xenopus laevis tissues.";
RL Mol. Vis. 17:1381-1396(2011).
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR EMBL; JF274981; AEG21035.1; -; mRNA.
DR AlphaFoldDB; F6LI76; -.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..855
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003343452"
FT TRANSMEM 108..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 279..313
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 855 AA; 95451 MW; 7B387A833588406C CRC64;
MAFKLYLVFL LFCGFTLSER TLPLNSAPAR LDFGYVPAES YETDAYHEPG AIGLLFHIVQ
GFLYIVQPNA FPQDLVRKVA QQKFGEIRND YQKPENVVLT LQTIHYEIGF IIAAVLGLVF
LLLMPLVGLC FCMCRCCDNC GGEMHQRQKK NGDCQRGCYS TFLFVTTLLI SVGVICAYAA
NQNLTNQIRG SKKLVQSNFK DLKTLLNDAP TQINYVLSKF NVTKDKALSE MNNLGPLLGE
RVHERLGKDV RPAFDAVLNM AGVKVQRAIK AIKETKEALE NVSLCVEVLQ EAIDRLNNNL
TEAKLQLTST LSDPACSANV ALIPCNKITS SLNQLNTNAN FSVLPDLSHN LIRLNEVLRT
DLSNLVQKGY AAFNSTPEMV QNQTRNIEGA AIPHMKNVLE SIGANITSFS KTAPVLQIMA
NINNHISQSE TYVREFYPVV EQYDFYRWLG SLVLCCMVSL IVVFYCLGLL CGTCGYDQHS
SPTTRGCITN TGGNFLMAGV GFSFIFSWIL MLIVVVTFLA GGNVQKLVCE PFQERSLFKV
LDTPYLINSQ WKNYLSGILY QNPNMNLTFE KVYSDCKENK GIFTALQIDN LLNLNEFLNI
NMYIDDISAK IETLNLDLST IVLLDEKGKR NLEDFSSTGL DEIDFDAFLS EVAKSNTKVD
LLAFANELEE NADLLPKGAL GNALKGHANS IRTIHIQQVV PLEQSMKYVK ARITLNQSIK
LLQRTSFDIE GKVLDVITAV EAAQNLINNN ASLIIKQESK KLMDEVIGYF IQYVQWVKDS
IAFDVAGCKP IANVVDTAVD VFLCSYIVDS VNSFWFGLGG ATVLLIPAII FAIRLAKFYR
RMDTEDVYDD ATEQW
//
